Intracellular signal transduction as a factor in the development of "Smart" biomaterials for bone tissue engineering

Willian F. Zambuzzi, Paulo G. Coelho, Gutemberg G. Alves, José M. Granjeiro

Research output: Contribution to journalReview articlepeer-review


Signal transduction involves studying the intracellular mechanisms that govern cellular responses to external stimuli such as hormones, cytokines, and also cell adhesion to biomaterials surfaces. Several events have been shown to be responsible for cellular adhesion and adaptation onto different surfaces. For instance, cytoskeletal rearrangements during cell adhesion require the recruitment of specific protein tyrosine kinases into focal adhesion structures that promote transient focal adhesion kinase and Src phosphorylations, initially modulating cell behavior. In addition, the phosphorylation of tyrosine (Y) residues have been generally accepted as a critical regulator of a wide range of cell-related processes, including cell proliferation, migration, differentiation, survival signalling, and energy metabolism. The understanding of the signaling involved on the mechanisms of osteoblast adhesion, proliferation, and differentiation on implant surfaces is fundamental for the successful design of novel "smart" materials, potentially decreasing the repair time, thereby allowing for faster patient rehabilitation.

Original languageEnglish (US)
Pages (from-to)1246-1250
Number of pages5
JournalBiotechnology and Bioengineering
Issue number6
StatePublished - Jun 2011


  • Bioengineering
  • Biotechnology
  • Cell adhesion
  • Implant
  • Material development
  • Signal transduction

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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