Intracellular transport: Relating single-molecule properties to in vivo function

G. T. Shubeita, S. P. Gross

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Single-molecule function of molecular motors has been well characterized in vitro, but in vivo, motors typically function as part of larger ensembles, including both regulatory proteins and multiple motors. Thus, single-molecule knowledge is only the start of the journey to understand cellular function and organization. The challenge is to use single-molecule information to quantitatively understand transport and its regulation in a cellular context. This article discusses this process focusing on kinesin and dynein, highlighting progress to date, and the challenges involved in using single-molecule function to understand in vivo transport.

Original languageEnglish (US)
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages287-297
Number of pages11
Volume4
ISBN (Print)9780080957180
DOIs
StatePublished - 2012

Keywords

  • BicD
  • Dynactin
  • Dynein
  • Ensemble function
  • In vitro
  • In vivo
  • Kinesin
  • Microtubule-based transport
  • Molecular motors
  • Motor regulation
  • Multiple motor
  • Regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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