Intragenic locus in human PIWIL2 gene shares promoter and enhancer functions

Yulia V. Skvortsova, Sofia A. Kondratieva, Marina V. Zinovyeva, Lev G. Nikolaev, Tatyana L. Azhikina, Ildar V. Gainetdinov

Research output: Contribution to journalArticlepeer-review


Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies broader impact on understanding enhancer-promoter networks in regulation of gene expression.

Original languageEnglish (US)
Article numbere0156454
JournalPloS one
Issue number6
StatePublished - Jun 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • General


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