Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake

Victoria N. Luine, Maya Frankfurt, Thomas C. Rainbow, Anat Biegon, Efrain Azmitia

Research output: Contribution to journalArticlepeer-review

Abstract

5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.

Original languageEnglish (US)
Pages (from-to)344-348
Number of pages5
JournalBrain Research
Volume264
Issue number2
DOIs
StatePublished - Apr 4 1983

Keywords

  • 5,7-dihydroxytryptamine
  • lordosis behavior
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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