Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake

Victoria N. Luine; Maya Frankfurt; Thomas C. Rainbow; Anat Biegon; Efrain Azmitia

doi:10.1016/0006-8993(83)90839-9

Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [³H]imipramine binding and 5-HT uptake

Victoria N. Luine, Maya Frankfurt, Thomas C. Rainbow, Anat Biegon, Efrain Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [³H]5-HT but not [³H]NE uptake in the whole hypothalamus and with decreased [³H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.

Original language	English (US)
Pages (from-to)	344-348
Number of pages	5
Journal	Brain Research
Volume	264
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(83)90839-9
State	Published - Apr 4 1983

Keywords

5,7-dihydroxytryptamine
lordosis behavior
serotonin

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(83)90839-9

Cite this

@article{b7668a1e58744684940e7e35b2f004fd,

title = "Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake",

abstract = "5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.",

keywords = "5,7-dihydroxytryptamine, lordosis behavior, serotonin",

author = "Luine, {Victoria N.} and Maya Frankfurt and Rainbow, {Thomas C.} and Anat Biegon and Efrain Azmitia",

note = "Funding Information: This work was supported by the following grants: HDI2011 to V.N.L., NS17431 and a Sloan Fellowship to T.C.R., NSF grant BNS79-064-74 and a Hirschl Career Award to E.C. and a Chaim Weizmann fellowship to A.B. We extend our thanks to Joseph Rhodes and Vernell Daniels for technical assistance.",

year = "1983",

month = apr,

day = "4",

doi = "10.1016/0006-8993(83)90839-9",

language = "English (US)",

volume = "264",

pages = "344--348",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

number = "2",

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T1 - Intrahypothalamic 5,7-dihydroxytryptamine facilitates feminine sexual behavior and decreases [3H]imipramine binding and 5-HT uptake

AU - Luine, Victoria N.

AU - Frankfurt, Maya

AU - Rainbow, Thomas C.

AU - Biegon, Anat

AU - Azmitia, Efrain

N1 - Funding Information: This work was supported by the following grants: HDI2011 to V.N.L., NS17431 and a Sloan Fellowship to T.C.R., NSF grant BNS79-064-74 and a Hirschl Career Award to E.C. and a Chaim Weizmann fellowship to A.B. We extend our thanks to Joseph Rhodes and Vernell Daniels for technical assistance.

PY - 1983/4/4

Y1 - 1983/4/4

N2 - 5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.

AB - 5,7-Dihydroxytryptamine (5,7-DHT) injected into the hypothalamus facilitated feminine sexual behavior in ovariectomized, estrogen-treated female rats beginning 9 days post-lesion. 5,7-DHT treatment was associated with decreased [3H]5-HT but not [3H]NE uptake in the whole hypothalamus and with decreased [3H]-imipramine binding in some hypothalamic nuclei. These data provide the first demonstration using chemical lesions that 5-HT neurons may exert tonic inhibition on hormone-mediated feminine sexual behavior.

KW - 5,7-dihydroxytryptamine

KW - lordosis behavior

KW - serotonin

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