TY - JOUR
T1 - Invited review article
T2 - Combining scanning probe microscopy with optical spectroscopy for applications in biology and materials science
AU - Lucas, Marcel
AU - Riedo, Elisa
N1 - Funding Information:
We acknowledge the support of the Office of Basic Energy Sciences of the US Department of Energy (DE-FG02-06ER46293). We also acknowledge partial support from the National Science Foundation (NSF) (CMMI-1100290 and DMR-0820382).
PY - 2012/6
Y1 - 2012/6
N2 - This is a comprehensive review of the combination of scanning probe microscopy (SPM) with various optical spectroscopies, with a particular focus on Raman spectroscopy. Efforts to combine SPM with optical spectroscopy will be described, and the technical difficulties encountered will be examined. These efforts have so far focused mainly on the development of tip-enhanced Raman spectroscopy, a powerful technique to detect and image chemical signatures with single molecule sensitivity, which will be reviewed. Beyond tip-enhanced Raman spectroscopy andor topography measurements, combinations of SPM with optical spectroscopy have a great potential in the characterization of structure and quantitative measurements of physical properties, such as mechanical, optical, or electrical properties, in delicate biological samples and nanomaterials. The different approaches to improve the spatial resolution, the chemical sensitivity, and the accuracy of physical properties measurements will be discussed. Applications of such combinations for the characterization of structure, defects, and physical properties in biology and materials science will be reviewed. Due to the versatility of SPM probes for the manipulation and characterization of small andor delicate samples, this review will mainly focus on the apertureless techniques based on SPM probes.
AB - This is a comprehensive review of the combination of scanning probe microscopy (SPM) with various optical spectroscopies, with a particular focus on Raman spectroscopy. Efforts to combine SPM with optical spectroscopy will be described, and the technical difficulties encountered will be examined. These efforts have so far focused mainly on the development of tip-enhanced Raman spectroscopy, a powerful technique to detect and image chemical signatures with single molecule sensitivity, which will be reviewed. Beyond tip-enhanced Raman spectroscopy andor topography measurements, combinations of SPM with optical spectroscopy have a great potential in the characterization of structure and quantitative measurements of physical properties, such as mechanical, optical, or electrical properties, in delicate biological samples and nanomaterials. The different approaches to improve the spatial resolution, the chemical sensitivity, and the accuracy of physical properties measurements will be discussed. Applications of such combinations for the characterization of structure, defects, and physical properties in biology and materials science will be reviewed. Due to the versatility of SPM probes for the manipulation and characterization of small andor delicate samples, this review will mainly focus on the apertureless techniques based on SPM probes.
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U2 - 10.1063/1.4720102
DO - 10.1063/1.4720102
M3 - Review article
C2 - 22755608
AN - SCOPUS:84863522371
SN - 0034-6748
VL - 83
JO - Review of Scientific Instruments
JF - Review of Scientific Instruments
IS - 6
M1 - 061101
ER -