Abstract
We present a biophysical model of a slowly inactivating potassium ion current IKS, based on recent voltage-clamp data from layer V pyramidal neurons in the cat sensori-motor cortex and show that the interplay between a persistent sodium current INaP and IKS is able to produce intrinsic membrane potential oscillations in the 10- to 50-frequency range. A most notable characteristic of such rhythmicity is what may be termed mixed-mode bursting, where clusters of action potentials alternate in time with epochs of small subthreshold oscillations.
Original language | English (US) |
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Pages (from-to) | 221-224 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1993 |
Keywords
- 40 hz brain rhythm
- Biophysical model
- Clustering of na spikes
- Hodgkin-huxley formalism
- Mixed-mode bursting
- Persistent sodium channel
- Slowly inactivating potassium channel
- Subthreshold oscillation
ASJC Scopus subject areas
- General Neuroscience