IOP elevation reduces schlemm's canal cross-sectional area

Larry Kagemann, Bo Wang, Gadi Wollstein, Hiroshi Ishikawa, Jessica E. Nevins, Zach Nadler, Ian A. Sigal, Richard A. Bilonick, Joel S. Schuman

    Research output: Contribution to journalArticle

    Abstract

    Purpose. Previously, we demonstrated reduced Schlemm's canal cross-sectional area (SC-CSA) with increased perfusion pressure in a cadaveric flow model. The purpose of the present study was to determine the effect of acute IOP elevation on SC-CSA in living human eyes. Methods. The temporal limbus of 27 eyes of 14 healthy subjects (10 male, 4 female, age 36 ± 13 years) was imaged by spectral-domain optical coherence tomography at baseline and with IOP elevation (ophthalmodynamometer set at 30-g force). Intraocular pressure was measured at baseline and with IOP elevation by Goldmann applanation tonometry. Vascular landmarks were used to identify corresponding locations in baseline and IOP elevation scan volumes. Schlemm's canal CSA at five locations within a 1-mm length of SC was measured in ImageJ as described previously. A linear mixed-effects model quantified the effect of IOP elevation on SC-CSA. Results. The mean IOP increase was 189%, and the mean SC-CSA decrease was 32% (P < 0.001). The estimate (95% confidence interval) for SC-CSA response to IOP change was -66.6 (-80.6 to -52.7) μm2/mm Hg. Conclusions. Acute IOP elevation significantly reduces SC-CSA in healthy eyes. Acute dynamic response to IOP elevation may be a useful future characterization of ocular health in the management of glaucoma.

    Original languageEnglish (US)
    Pages (from-to)1805-1809
    Number of pages5
    JournalInvestigative Ophthalmology and Visual Science
    Volume55
    Issue number3
    DOIs
    StatePublished - Feb 13 2014

    Keywords

    • Ophthalmodynamometer
    • Optical coherence tomography
    • Outflow tract imaging

    ASJC Scopus subject areas

    • Ophthalmology
    • Sensory Systems
    • Cellular and Molecular Neuroscience

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  • Cite this

    Kagemann, L., Wang, B., Wollstein, G., Ishikawa, H., Nevins, J. E., Nadler, Z., Sigal, I. A., Bilonick, R. A., & Schuman, J. S. (2014). IOP elevation reduces schlemm's canal cross-sectional area. Investigative Ophthalmology and Visual Science, 55(3), 1805-1809. https://doi.org/10.1167/iovs.13-13264