Is periodontitis a risk factor for lung cancer? A meta-analysis and detailed review of mechanisms of association

Pooja Kesharani, Payalben Kansara, Tikal Kansara, Arjun Kini, Raksha Bhat, Preethesh Shetty, Bapanaiah Penugonda

Research output: Contribution to journalReview articlepeer-review


Background: Numerous studies have explored the correlation of periodontal disease (PD) with the risk of lung cancers, but the findings were inconsistent. Therefore, we did a meta-analysis to ascertain the correlation of PD with the risk of incident lung cancer. Methods: The authors searched relevant studies in databases (PubMed, Web of Science, Scopus, Embase, and MEDLINE) till November 2020. We registered the study at the International database of Prospectively Registered Systemic Reviews under the CRD42020198119. The summary relative risk (RR) along with a 95% confidence interval (CI) was calculated using fixed-effects models. Results: Twelve studies were included in the qualitative synthesis. The pooled analysis revealed that PD was significantly associated with an increased risk of lung cancer (RR 1.71; 95%CI 1.61-1.81; P < 0.01). Subgroup analysis was performed based on gender distribution, geographic location, and type of studies. Conclusion: From this current evidence, PD is a potential risk factor for the development of lung cancer. The risk for incidence of lung cancer is surged twice in the patients with PD, even though age and smoking are controlled in the studies.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalContemporary Clinical Dentistry
Issue number4
StatePublished - Oct 2022


  • Lung cancer
  • meta-analysis
  • periodontitis
  • systemic review

ASJC Scopus subject areas

  • Orthodontics
  • Oral Surgery
  • Periodontics


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