TY - JOUR
T1 - Isabella L. Karle
T2 - A Crystallography Pioneer
AU - Schlick, Tamar
N1 - Funding Information:
Support from NIH R35GM122562 from the National Institutes of Health and NSF RAPID Award 2030377 from the Division of Mathematical Sciences and the Division of Chemistry to T.S. are gratefully acknowledged.
Publisher Copyright:
© 2021, Mary Ann Liebert, Inc., publishers 2021.
PY - 2021/7
Y1 - 2021/7
N2 - The life and work of crystallography pioneer Isabella L. Karle is recounted (1921-2017), as researched from the literature and personal stories of colleagues and family. Her story includes her family background, education at the University of Michigan, research on the Manhattan Project, and 63 productive years at the Naval Research Laboratory. Her life-long partnership and scientific collaboration with husband Jerome Karle, 1985 Nobel Prize winner in Chemistry with Herbert Hauptman, is a big part of her story; however, Isabella has also established herself as a crystallographer extraordinaire through her Symbolic Addition Procedure to solve the phase problem, and her unique ability to solve the structures of complex biological molecules, including toxins, antibiotics, and peptides. Her rich family life with three daughters in a lake-front home, do-it-yourself attitude, and passions outside of science round up this portrait of a fascinating and brilliant woman.
AB - The life and work of crystallography pioneer Isabella L. Karle is recounted (1921-2017), as researched from the literature and personal stories of colleagues and family. Her story includes her family background, education at the University of Michigan, research on the Manhattan Project, and 63 productive years at the Naval Research Laboratory. Her life-long partnership and scientific collaboration with husband Jerome Karle, 1985 Nobel Prize winner in Chemistry with Herbert Hauptman, is a big part of her story; however, Isabella has also established herself as a crystallographer extraordinaire through her Symbolic Addition Procedure to solve the phase problem, and her unique ability to solve the structures of complex biological molecules, including toxins, antibiotics, and peptides. Her rich family life with three daughters in a lake-front home, do-it-yourself attitude, and passions outside of science round up this portrait of a fascinating and brilliant woman.
KW - Isabella Karle
KW - Nobel prize
KW - X-ray diffraction
KW - biography
KW - crystallography
KW - phase problem
UR - http://www.scopus.com/inward/record.url?scp=85111053305&partnerID=8YFLogxK
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U2 - 10.1089/dna.2021.0372
DO - 10.1089/dna.2021.0372
M3 - Review article
C2 - 34129390
AN - SCOPUS:85111053305
SN - 1044-5498
VL - 40
SP - 843
EP - 847
JO - DNA and cell biology
JF - DNA and cell biology
IS - 7
ER -