@article{784016499a6547729a9c70d5489826ef,
title = "Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions",
abstract = "Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to physiological and pathological cues. Mutations in actin regulators that are differentially expressed or enriched in immune cells cause severe human diseases known as primary immunodeficiencies underscoring the importance of efficienct actin remodeling in immune cell homeostasis. Here we discuss recent findings on how immune cells sense the mechanical properties of their environement. Moreover, while the organization and biochemical regulation of cytoplasmic actin have been extensively studied, nuclear actin reorganization is a rapidly emerging field that has only begun to be explored in immune cells. Based on the critical and multifaceted contributions of cytoplasmic actin in immune cell functionality, nuclear actin regulation is anticipated to have a large impact on our understanding of immune cell development and functionality.",
keywords = "actin, cytoplasm, immune cells, mechanosensing, nucleus",
author = "Julien Record and Saeed, {Mezida B.} and Tomas Venit and Piergiorgio Percipalle and Westerberg, {Lisa S.}",
note = "Funding Information: Illustrations were generated using Biorender.com. Funding. This work was supported by postdoctoral fellowships from the Childhood Cancer Fund and the Swedish Society for Medical Research to JR, the Swedish Research Council, Cancer Society, Childhood Cancer Fund, a StratCan Blue Sky award, the European Commission 7th Framework Program Marie Curie Reintegration Grant (#249177), {\AA}ke Olsson Foundation, {\AA}ke Wiberg Foundation, Bergvall Foundation, King Gustaf V{\textquoteright}s 80-year Foundation, and Karolinska Institutet to LW. LW is a Ragnar S derberg Fellow in Medicine and holds a Senior Researcher Position supported by the Childhood Cancer Fund. Funding Information: This work was supported by postdoctoral fellowships from the Childhood Cancer Fund and the Swedish Society for Medical Research to JR, the Swedish Research Council, Cancer Society, Childhood Cancer Fund, a StratCan Blue Sky award, the European Commission 7th Framework Program Marie Curie Reintegration Grant (#249177), {\AA}ke Olsson Foundation, {\AA}ke Wiberg Foundation, Bergvall Foundation, King Gustaf Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Record, Saeed, Venit, Percipalle and Westerberg.",
year = "2021",
month = aug,
day = "5",
doi = "10.3389/fcell.2021.682294",
language = "English (US)",
volume = "9",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media S. A.",
}