Kinetic resolution of hydroperoxides with enantiopure phosphines: Preparation of enantioenriched tertiary hydroperoxides

Tom G. Driver, Jason R. Harris, K. A. Woerpel

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient reductive kinetic resolution strategy capable of accessing optically active tertiary hydroperoxides is reported. Readily accessible tertiary hydroperoxides are resolved with commercially available (R)- or (S)-xylyl-PHANEPHOS with selectivity factors as large as 37. The resulting bis(phosphine oxide) can be recycled in high yields. The isolated mono(phosphine oxide) intermediate resolved hydroperoxides with the same selectivity as the parent bisphosphine.

Original languageEnglish (US)
Pages (from-to)3836-3837
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number13
DOIs
StatePublished - Apr 4 2007

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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