Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

K. W. Kinnally; H. Tedeschi; C. A. Mannella; H. L. Frisch

doi:10.1016/S0006-3495(89)82916-9

Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

K. W. Kinnally, H. Tedeschi, C. A. Mannella, H. L. Frisch

Research output: Contribution to journal › Article › peer-review

Abstract

The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.

Original language	English (US)
Pages (from-to)	1205-1213
Number of pages	9
Journal	Biophysical journal
Volume	55
Issue number	6
DOIs	https://doi.org/10.1016/S0006-3495(89)82916-9
State	Published - 1989

ASJC Scopus subject areas

Biophysics

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10.1016/S0006-3495(89)82916-9

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title = "Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane",

abstract = "The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.",

author = "Kinnally, {K. W.} and H. Tedeschi and Mannella, {C. A.} and Frisch, {H. L.}",

note = "Funding Information: David Tieman (Department of Biological Sciences, State University of New York at Albany) guided us through the use of the microcomputers and developed some of the software. This study was supported in part by ONR grant N0001485-K-0681 (H. Tedeschi), and National Science Foundation grants DMB-8613702 (C. Mannella) and DMR-8515519 (H. Frisch).",

year = "1989",

doi = "10.1016/S0006-3495(89)82916-9",

language = "English (US)",

volume = "55",

pages = "1205--1213",

journal = "Biophysical journal",

issn = "0006-3495",

publisher = "Biophysical Society",

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TY - JOUR

T1 - Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

AU - Kinnally, K. W.

AU - Tedeschi, H.

AU - Mannella, C. A.

AU - Frisch, H. L.

N1 - Funding Information: David Tieman (Department of Biological Sciences, State University of New York at Albany) guided us through the use of the microcomputers and developed some of the software. This study was supported in part by ONR grant N0001485-K-0681 (H. Tedeschi), and National Science Foundation grants DMB-8613702 (C. Mannella) and DMR-8515519 (H. Frisch).

PY - 1989

Y1 - 1989

N2 - The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.

AB - The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.

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JO - Biophysical journal

JF - Biophysical journal

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ER -

Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

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