Kinetics of voltage-induced conductance increases in the outer mitochondrial membrane

K. W. Kinnally, H. Tedeschi, C. A. Mannella, H. L. Frisch

Research output: Contribution to journalArticle

Abstract

The kinetics of the increase in conductance in the outer mitochondrial membrane induced by patch-clamping at various negative potentials (pipette inside negative) are reported. The changes are biphasic, a rapid increase is followed by a slowly developing larger change. The results can be predicted by a model in which an initial activation of channels is followed by their assembly into highly conducting channels. The model suggests that five to seven activated subunits form each high-conductance channel.

Original languageEnglish (US)
Pages (from-to)1205-1213
Number of pages9
JournalBiophysical journal
Volume55
Issue number6
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biophysics

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