Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator

Soha Yousuf, Jongmin Kim, Ajymurat Orozaliev, Marcus Dahlem, Yong Ak Song, Jaime Viegas

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.

Original languageEnglish (US)
JournalIEEE Photonics Journal
Volume13
Issue number4
DOIs
StatePublished - Aug 2021

Keywords

  • bio-sensor
  • label-free
  • micro-ring resonator
  • Morpholino-DNA hybridization

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering

Fingerprint

Dive into the research topics of 'Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator'. Together they form a unique fingerprint.

Cite this