TY - JOUR
T1 - Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator
AU - Yousuf, Soha
AU - Kim, Jongmin
AU - Orozaliev, Ajymurat
AU - Dahlem, Marcus
AU - Song, Yong Ak
AU - Viegas, Jaime
N1 - Funding Information:
Manuscript received April 6, 2021; revised July 9, 2021; accepted July 15, 2021. Date of publication July 21, 2021; date of current version September 9, 2021. This work was supported in parts by the Mubadala Development Company, Abu Dhabi, Economic Development Board, Singapore, and GlobalFoundries, Singapore under the framework of the ‘Twinlab’ project, with participation of A*STAR Institute of Microelectronics, Singapore, and in part by the Khalifa University under Grants CIRA-2018-110 and CRPA-2020-019. (Corresponding author: Soha Yousuf.) Soha Yousuf was with the Department of Electrical Engineering and Computer Science, Khalifa University of Science and Technology, Sas Al Nakhl Campus, Abu Dhabi 127788, UAE. He is currently with the Division of Science, New York University Abu Dhabi, Abu Dhabi 129188, UAE (e-mail: [email protected]).
Publisher Copyright:
© 2009-2012 IEEE.
PY - 2021/8
Y1 - 2021/8
N2 - In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.
AB - In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.
KW - Morpholino-DNA hybridization
KW - bio-sensor
KW - label-free
KW - micro-ring resonator
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U2 - 10.1109/JPHOT.2021.3098680
DO - 10.1109/JPHOT.2021.3098680
M3 - Article
AN - SCOPUS:85111054950
SN - 1943-0655
VL - 13
JO - IEEE Photonics Journal
JF - IEEE Photonics Journal
IS - 4
ER -