Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator

Soha Yousuf; Jongmin Kim; Ajymurat Orozaliev; Marcus Dahlem; Yong Ak Song; Jaime Viegas

doi:10.1109/JPHOT.2021.3098680

Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator

Soha Yousuf, Jongmin Kim, Ajymurat Orozaliev, Marcus Dahlem, Yong Ak Song, Jaime Viegas

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.

Original language	English (US)
Journal	IEEE Photonics Journal
Volume	13
Issue number	4
DOIs	https://doi.org/10.1109/JPHOT.2021.3098680
State	Published - Aug 2021

Keywords

Morpholino-DNA hybridization
bio-sensor
label-free
micro-ring resonator

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Electrical and Electronic Engineering

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10.1109/JPHOT.2021.3098680

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title = "Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator",

abstract = "In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.",

keywords = "Morpholino-DNA hybridization, bio-sensor, label-free, micro-ring resonator",

author = "Soha Yousuf and Jongmin Kim and Ajymurat Orozaliev and Marcus Dahlem and Song, {Yong Ak} and Jaime Viegas",

note = "Funding Information: Manuscript received April 6, 2021; revised July 9, 2021; accepted July 15, 2021. Date of publication July 21, 2021; date of current version September 9, 2021. This work was supported in parts by the Mubadala Development Company, Abu Dhabi, Economic Development Board, Singapore, and GlobalFoundries, Singapore under the framework of the {\textquoteleft}Twinlab{\textquoteright} project, with participation of A*STAR Institute of Microelectronics, Singapore, and in part by the Khalifa University under Grants CIRA-2018-110 and CRPA-2020-019. (Corresponding author: Soha Yousuf.) Soha Yousuf was with the Department of Electrical Engineering and Computer Science, Khalifa University of Science and Technology, Sas Al Nakhl Campus, Abu Dhabi 127788, UAE. He is currently with the Division of Science, New York University Abu Dhabi, Abu Dhabi 129188, UAE (e-mail: sohaekrima@gmail.com). Publisher Copyright: {\textcopyright} 2009-2012 IEEE.",

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AU - Dahlem, Marcus

AU - Song, Yong Ak

AU - Viegas, Jaime

N1 - Funding Information: Manuscript received April 6, 2021; revised July 9, 2021; accepted July 15, 2021. Date of publication July 21, 2021; date of current version September 9, 2021. This work was supported in parts by the Mubadala Development Company, Abu Dhabi, Economic Development Board, Singapore, and GlobalFoundries, Singapore under the framework of the ‘Twinlab’ project, with participation of A*STAR Institute of Microelectronics, Singapore, and in part by the Khalifa University under Grants CIRA-2018-110 and CRPA-2020-019. (Corresponding author: Soha Yousuf.) Soha Yousuf was with the Department of Electrical Engineering and Computer Science, Khalifa University of Science and Technology, Sas Al Nakhl Campus, Abu Dhabi 127788, UAE. He is currently with the Division of Science, New York University Abu Dhabi, Abu Dhabi 129188, UAE (e-mail: sohaekrima@gmail.com). Publisher Copyright: © 2009-2012 IEEE.

PY - 2021/8

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N2 - In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.

AB - In this study, deoxyribonucleic acid (DNA) hybridization was demonstrated using a suspended silicon photonics micro-ring resonator with a 90 nm-Thick slab and morpholino as the capture probe. Complementary DNA of various concentrations were tested achieving a surface sensitivity of 2.12 nm/nM, a detection limit of 250 pM, and an intrinsic detection limit of 36.9 pM. A bulk sensitivity of 98 nm/RIU and an intrinsic detection limit of $1.03\times 10^{-3}$ RIU was also measured upon exposure to isopropanol/deionized water solutions. With these characteristics, the suspended 90 nm slab ring sensor proved as a promising candidate for lab-on-A-chip bio-sensing applications.

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Label-Free Detection of Morpholino-DNA Hybridization Using a Silicon Photonics Suspended Slab Micro-Ring Resonator

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Keywords

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