@inproceedings{e94961af3e8945bdb39c968c87c58284,
title = "Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor",
abstract = "The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.",
keywords = "Whispering gallery mode, biosensing, microcavity, photonics, plasmonics, reactive sensing principle, resonance, single protein",
author = "S. Holler and Dantham, {V. R.} and D. Keng and V. Kolchenko and Stephen Arnold",
year = "2014",
doi = "10.1117/12.2050222",
language = "English (US)",
isbn = "9781628410495",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
booktitle = "Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV",
note = "Sensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV ; Conference date: 05-05-2014 Through 07-05-2014",
}