Label-free single cancer marker protein detection using a nanoplasmonic-photonic hybrid whispering gallery mode biosensor

S. Holler, V. R. Dantham, D. Keng, V. Kolchenko, Stephen Arnold

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The reactive sensing principle applied to hybrid plasmonic whispering gallery mode biosensor has recently demonstrated detection of individual protein cancer markers. The rough surface of a gold nanoparticle affixed to the resonator surface acts like a nanoscopic antenna, significantly boosts the local electric field within the cavity mode. Adsorption of a target protein onto this nanoscopic antenna results in an enhanced response of the resonator system to the binding event. We have demonstrated detection of individual protein molecules (66 kDa) with good signal-to-noise (S/N > 10), and project that detection of proteins as small as 5 kDa are possible.

Original languageEnglish (US)
Title of host publicationSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV
PublisherSPIE
ISBN (Print)9781628410495
DOIs
StatePublished - 2014
EventSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV - Baltimore, MD, United States
Duration: May 5 2014May 7 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9112
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherSensing Technologies for Global Health, Military Medicine, and Environmental Monitoring IV
CountryUnited States
CityBaltimore, MD
Period5/5/145/7/14

Keywords

  • Whispering gallery mode
  • biosensing
  • microcavity
  • photonics
  • plasmonics
  • reactive sensing principle
  • resonance
  • single protein

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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