Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+

Brismar Pinto-Pacheco; Qitian Lin; Claudia W. Yan; Symara de Melo Silva; Daniela Buccella

doi:10.1039/d2cc07095b

Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg²⁺

Brismar Pinto-Pacheco, Qitian Lin, Claudia W. Yan, Symara de Melo Silva, Daniela Buccella

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Biomolecule-bound Mg²⁺ species, particularly polyphosphate complexes, represent a large and dynamic fraction of the total cellular magnesium that is essential for cellular function but remains invisible to most indicators. Here we report a new family of Eu(iii)-based indicators, the MagQEu family, functionalized with a 4-oxo-4H-quinolizine-3-carboxylic acid metal recognition group/sensitization antenna for turn-on, luminescence-based detection of biologically relevant Mg²⁺ species.

Original language	English (US)
Pages (from-to)	3586-3589
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	24
DOIs	https://doi.org/10.1039/d2cc07095b
State	Published - Feb 28 2023

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/d2cc07095b

Cite this

@article{0110dde0af2b43858af188b06a509399,

title = "Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg2+",

abstract = "Biomolecule-bound Mg2+ species, particularly polyphosphate complexes, represent a large and dynamic fraction of the total cellular magnesium that is essential for cellular function but remains invisible to most indicators. Here we report a new family of Eu(iii)-based indicators, the MagQEu family, functionalized with a 4-oxo-4H-quinolizine-3-carboxylic acid metal recognition group/sensitization antenna for turn-on, luminescence-based detection of biologically relevant Mg2+ species.",

author = "Brismar Pinto-Pacheco and Qitian Lin and Yan, {Claudia W.} and {de Melo Silva}, Symara and Daniela Buccella",

note = "Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = feb,

day = "28",

doi = "10.1039/d2cc07095b",

language = "English (US)",

volume = "59",

pages = "3586--3589",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "24",

}

TY - JOUR

T1 - Lanthanide-based luminescent probes for biological magnesium

T2 - accessing polyphosphate-bound Mg2+

AU - Pinto-Pacheco, Brismar

AU - Lin, Qitian

AU - Yan, Claudia W.

AU - de Melo Silva, Symara

AU - Buccella, Daniela

PY - 2023/2/28

Y1 - 2023/2/28

N2 - Biomolecule-bound Mg2+ species, particularly polyphosphate complexes, represent a large and dynamic fraction of the total cellular magnesium that is essential for cellular function but remains invisible to most indicators. Here we report a new family of Eu(iii)-based indicators, the MagQEu family, functionalized with a 4-oxo-4H-quinolizine-3-carboxylic acid metal recognition group/sensitization antenna for turn-on, luminescence-based detection of biologically relevant Mg2+ species.

AB - Biomolecule-bound Mg2+ species, particularly polyphosphate complexes, represent a large and dynamic fraction of the total cellular magnesium that is essential for cellular function but remains invisible to most indicators. Here we report a new family of Eu(iii)-based indicators, the MagQEu family, functionalized with a 4-oxo-4H-quinolizine-3-carboxylic acid metal recognition group/sensitization antenna for turn-on, luminescence-based detection of biologically relevant Mg2+ species.

UR - http://www.scopus.com/inward/record.url?scp=85149882018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85149882018&partnerID=8YFLogxK

U2 - 10.1039/d2cc07095b

DO - 10.1039/d2cc07095b

M3 - Article

C2 - 36883365

AN - SCOPUS:85149882018

SN - 1359-7345

VL - 59

SP - 3586

EP - 3589

JO - Chemical Communications

JF - Chemical Communications

IS - 24

ER -

Lanthanide-based luminescent probes for biological magnesium: accessing polyphosphate-bound Mg²⁺

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this