Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Talha S. Siddiqui; Ashish Jani; Florence Williams; Robert N. Muller; Luce Vander Elst; Sophie Laurent; Fang Yao; Youssef Zaim Wadghiri; Marc A. Walters

doi:10.1016/j.jcis.2009.04.096

Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Talha S. Siddiqui, Ashish Jani, Florence Williams, Robert N. Muller, Luce Vander Elst, Sophie Laurent, Fang Yao, Youssef Zaim Wadghiri, Marc A. Walters

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This paper describes colloidal particles that are designed to induce hyper-intensity contrast (T₁ relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)]^2- and (2) [Gd(cystine-NTA)₂]^3-, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r₁ relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s^-1 mM^-1, respectively, as compared to 4.7 s^-1 mM^-1 for the clinical agent Magnevist^TM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s^-1 mM^-1.

Original language	English (US)
Pages (from-to)	88-96
Number of pages	9
Journal	Journal of Colloid And Interface Science
Volume	337
Issue number	1
DOIs	https://doi.org/10.1016/j.jcis.2009.04.096
State	Published - Sep 1 2009

Keywords

Contrast
Longitudinal relaxation
MRI
Monolayer protected
Nanoparticles
Relaxivity
Silver

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

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10.1016/j.jcis.2009.04.096

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title = "Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging",

abstract = "This paper describes colloidal particles that are designed to induce hyper-intensity contrast (T1 relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)]2- and (2) [Gd(cystine-NTA)2]3-, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s-1 mM-1, respectively, as compared to 4.7 s-1 mM-1 for the clinical agent MagnevistTM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s-1 mM-1.",

keywords = "Contrast, Longitudinal relaxation, MRI, Monolayer protected, Nanoparticles, Relaxivity, Silver",

author = "Siddiqui, {Talha S.} and Ashish Jani and Florence Williams and Muller, {Robert N.} and Elst, {Luce Vander} and Sophie Laurent and Fang Yao and Wadghiri, {Youssef Zaim} and Walters, {Marc A.}",

note = "Funding Information: This work was supported in part by a grant from the Tilker Medical Research Foundation (Y.Z.W. and M.A.W.). We wish to thank Dr. Alice Liang for the acquisition of electron micrographs. We thank Dr. Chin Lin for assistance in the NMR analyses. This work was supported by the FNRS and the ARC Program 05/10-335 of the French Community of Belgium. The support and sponsorship concerted by COST Action D38 and the EMIL project are kindly acknowledged (R.M.). ",

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doi = "10.1016/j.jcis.2009.04.096",

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T2 - Designing contrast agents for magnetic resonance imaging

AU - Siddiqui, Talha S.

AU - Jani, Ashish

AU - Williams, Florence

AU - Muller, Robert N.

AU - Elst, Luce Vander

AU - Laurent, Sophie

AU - Yao, Fang

AU - Wadghiri, Youssef Zaim

AU - Walters, Marc A.

N1 - Funding Information: This work was supported in part by a grant from the Tilker Medical Research Foundation (Y.Z.W. and M.A.W.). We wish to thank Dr. Alice Liang for the acquisition of electron micrographs. We thank Dr. Chin Lin for assistance in the NMR analyses. This work was supported by the FNRS and the ARC Program 05/10-335 of the French Community of Belgium. The support and sponsorship concerted by COST Action D38 and the EMIL project are kindly acknowledged (R.M.).

PY - 2009/9/1

Y1 - 2009/9/1

N2 - This paper describes colloidal particles that are designed to induce hyper-intensity contrast (T1 relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)]2- and (2) [Gd(cystine-NTA)2]3-, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s-1 mM-1, respectively, as compared to 4.7 s-1 mM-1 for the clinical agent MagnevistTM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s-1 mM-1.

AB - This paper describes colloidal particles that are designed to induce hyper-intensity contrast (T1 relaxation) in MRI. The contrast agents consist of discrete gadolinium complexes tethered to 10 nm diameter silver nanoparticles. The gadolinium complexes (1) [Gd(DTPA-bisamido cysteine)]2- and (2) [Gd(cystine-NTA)2]3-, undergo chemisorption to particle surfaces through thiol or disulfide groups, respectively, to form two new contrast agents. The resulting nanoparticulate constructs are characterized on the basis of their syntheses, composition, spectra and contrast enhancing power. The average r1 relaxivities of the of the surface bound complexes (obtained at 9.4 T and 25 °C) are 10.7 and 9.7 s-1 mM-1, respectively, as compared to 4.7 s-1 mM-1 for the clinical agent MagnevistTM. Correspondingly, the respective whole particle relaxivities are 27927 and 13153 s-1 mM-1.

KW - Contrast

KW - Longitudinal relaxation

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KW - Monolayer protected

KW - Nanoparticles

KW - Relaxivity

KW - Silver

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Lanthanide complexes on Ag nanoparticles: Designing contrast agents for magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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