Lateralization of striatal dopamine (D2) receptors in normal rats

Linda H. Schneider; Randall B. Murphy; Edgar E. Coons

doi:10.1016/0304-3940(82)90385-8

Lateralization of striatal dopamine (D2) receptors in normal rats

Linda H. Schneider, Randall B. Murphy, Edgar E. Coons

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

A highly significant andogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [³H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, while in mesolimbic terminal zones 10% more binding was observed on the right than on the left. These data provide evidence for an intrinsic lateralization of neuroleptic (D2) receptors in the rat brain, and are consistent with prior determinations of endogenous asymmetries in neurochemical and behavioral indices of dopaminergic function in the nigrostriatal system.

Original language	English (US)
Pages (from-to)	281-284
Number of pages	4
Journal	Neuroscience letters
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(82)90385-8
State	Published - Dec 13 1982

Keywords

dopamine receptors
lateralization
nigrostriatal system

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0304-3940(82)90385-8

Cite this

@article{4010c447eec44e2f95f0661c59580a70,

title = "Lateralization of striatal dopamine (D2) receptors in normal rats",

abstract = "A highly significant andogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [3H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, while in mesolimbic terminal zones 10% more binding was observed on the right than on the left. These data provide evidence for an intrinsic lateralization of neuroleptic (D2) receptors in the rat brain, and are consistent with prior determinations of endogenous asymmetries in neurochemical and behavioral indices of dopaminergic function in the nigrostriatal system.",

keywords = "dopamine receptors, lateralization, nigrostriatal system",

author = "Schneider, {Linda H.} and Murphy, {Randall B.} and Coons, {Edgar E.}",

year = "1982",

month = dec,

day = "13",

doi = "10.1016/0304-3940(82)90385-8",

language = "English (US)",

volume = "33",

pages = "281--284",

journal = "Neuroscience letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Lateralization of striatal dopamine (D2) receptors in normal rats

AU - Schneider, Linda H.

AU - Murphy, Randall B.

AU - Coons, Edgar E.

PY - 1982/12/13

Y1 - 1982/12/13

N2 - A highly significant andogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [3H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, while in mesolimbic terminal zones 10% more binding was observed on the right than on the left. These data provide evidence for an intrinsic lateralization of neuroleptic (D2) receptors in the rat brain, and are consistent with prior determinations of endogenous asymmetries in neurochemical and behavioral indices of dopaminergic function in the nigrostriatal system.

AB - A highly significant andogenous lateral asymmetry in striatal dopamine (D2) receptors was found utilizing the binding of [3H]spiroperidol (0.6 nM) to homogenates prepared from the left and the right striata of male rats individually assayed. The mean level of binding was 23% greater in left than in right striatum, while in mesolimbic terminal zones 10% more binding was observed on the right than on the left. These data provide evidence for an intrinsic lateralization of neuroleptic (D2) receptors in the rat brain, and are consistent with prior determinations of endogenous asymmetries in neurochemical and behavioral indices of dopaminergic function in the nigrostriatal system.

KW - dopamine receptors

KW - lateralization

KW - nigrostriatal system

UR - http://www.scopus.com/inward/record.url?scp=0020306555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020306555&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(82)90385-8

DO - 10.1016/0304-3940(82)90385-8

M3 - Article

C2 - 7162690

AN - SCOPUS:0020306555

SN - 0304-3940

VL - 33

SP - 281

EP - 284

JO - Neuroscience letters

JF - Neuroscience letters

IS - 3

ER -

Lateralization of striatal dopamine (D2) receptors in normal rats

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this