Learning biological networks: From modules to dynamics

Research output: Contribution to journalReview articlepeer-review

Abstract

Learning regulatory networks from genomics data is an important problem with applications spanning all of biology and biomedicine. Functional genomics projects offer a cost-effective means of greatly expanding the completeness of our regulatory models, and for some prokaryotic organisms they offer a means of learning accurate models that incorporate the majority of the genome. There are, however, several reasons to believe that regulatory network inference is beyond our current reach, such as (i) the combinatorics of the problem, (ii) factors we can't (or don't often) collect genome-wide measurements for and (iii) dynamics that elude cost-effective experimental designs. Recent works have demonstrated the ability to reconstruct large fractions of prokaryotic regulatory networks from compendiums of genomics data; they have also demonstrated that these global regulatory models can be used to predict the dynamics of the transcriptome. We review an overall strategy for the reconstruction of global networks based on these results in microbial systems.

Original languageEnglish (US)
Pages (from-to)658-664
Number of pages7
JournalNature Chemical Biology
Volume4
Issue number11
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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