Leptin, lipid and lipid metabolism-related hormones in chronic renal failure in Arabia

Enyioma N. Obineche, Michael P.T. Gillett, Abdishakur Abdulle, Mustapha Sulaiman, Mona Al-Rokhaimi

Research output: Contribution to journalArticle

Abstract

In patients with chronic renal failure (CRF), hyperleptinaemia has been widely reported, but the exact mechanisms leading to elevated leptin levels are unclear. Impaired renal clearance of leptin and the influence of other hormones may be important. In this study, we measured serum leptin levels in 150 patients on haemodialysis, peritoneal dialysis or in the predialysis phase of CRF. Furthermore, we measured plasma levels of insulin, growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as well as plasma levels of triacylglycerols and total low density lipoprotein (LDL)- and high density lipoprotein (HDL)-cholesterol. We observed significantly elevated levels of leptin, particularly in female patients, and leptin was shown to correlate significantly with insulin, total and LDL-cholesterol and log triacylglycerols. Leptin was inversely correlated with GH concentrations, but was not correlated with IGF-1 levels. Despite the multiple correlations established between leptin levels and other variables, only hyperinsulinaemia in CRF seems to be important as a determinator of leptin levels.

Original languageEnglish (US)
Pages (from-to)115-120
Number of pages6
JournalNephrology
Volume7
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Chronic renal failure
  • Growth hormone
  • Insulin
  • Insulin-like growth factor 1
  • Leptin
  • Lipids
  • United Arab Emirates

ASJC Scopus subject areas

  • Nephrology

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