Light dosimetry in PDT using optical fiber delivery

Steven L. Jacques; Martin Ostermeyer; Lihong Wang; Andreas Hielscher

doi:10.1117/12.179977

Light dosimetry in PDT using optical fiber delivery

Steven L. Jacques, Martin Ostermeyer, Lihong Wang, Andreas Hielscher

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The paper considers rapid calculations of light distributions in a tissue for photodynamic therapy. The delivery system considered is a single optical fiber, although other configurations are easily modeled. The influence of optical heterogeneities in the tissue is considered. The optical distributions surrounding an optical fiber within a tissue can be well approximated by a point source of light placed one "reduced mean free path" (mfp') in front of the fiber tip. One mfp' equals 1/(μ_a + μ_s(1-g)). Then the simple diffusion theory expression for 3D diffusion from a point source predicts the light distribution in the tissue. The influence of optical heterogeneities in the tissue can also be well approximated. A method is described for representing regions of increased absorption (such as a region with increased vascularity) as virtual sources of "negative radiant power" such that linear superposition of the true primary source and the virtual sources yields the net light distribution in the heterogeneous tissue. The method is rapid, flexible, and generally accurate to within about 15 % error. The method yields light distributions in optically complex tissues.

Original language	English (US)
Title of host publication	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994
Subtitle of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Pages	140-149
Number of pages	10
Volume	2133
DOIs	https://doi.org/10.1117/12.179977
State	Published - Jul 19 1994
Event	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994 - Los Angeles, United States Duration: Jan 23 1994 → Jan 29 1994

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Publisher	SPIE
ISSN (Print)	0277-786X

Conference

Conference	Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994
Country/Territory	United States
City	Los Angeles
Period	1/23/94 → 1/29/94

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.179977

Cite this

Jacques, S. L., Ostermeyer, M., Wang, L., & Hielscher, A. (1994). Light dosimetry in PDT using optical fiber delivery. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994: Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2133, pp. 140-149). (Proceedings of SPIE - The International Society for Optical Engineering). https://doi.org/10.1117/12.179977

Light dosimetry in PDT using optical fiber delivery. / Jacques, Steven L.; Ostermeyer, Martin; Wang, Lihong et al.
Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2133 1994. p. 140-149 (Proceedings of SPIE - The International Society for Optical Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jacques, SL, Ostermeyer, M, Wang, L & Hielscher, A 1994, Light dosimetry in PDT using optical fiber delivery. in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994: Proceedings of SPIE - The International Society for Optical Engineering. vol. 2133, Proceedings of SPIE - The International Society for Optical Engineering, pp. 140-149, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994, Los Angeles, United States, 1/23/94. https://doi.org/10.1117/12.179977

Jacques SL, Ostermeyer M, Wang L, Hielscher A. Light dosimetry in PDT using optical fiber delivery. In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2133. 1994. p. 140-149. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.179977

Jacques, Steven L. ; Ostermeyer, Martin ; Wang, Lihong et al. / Light dosimetry in PDT using optical fiber delivery. Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994: Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2133 1994. pp. 140-149 (Proceedings of SPIE - The International Society for Optical Engineering).

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abstract = "The paper considers rapid calculations of light distributions in a tissue for photodynamic therapy. The delivery system considered is a single optical fiber, although other configurations are easily modeled. The influence of optical heterogeneities in the tissue is considered. The optical distributions surrounding an optical fiber within a tissue can be well approximated by a point source of light placed one {"}reduced mean free path{"} (mfp') in front of the fiber tip. One mfp' equals 1/(μa + μs(1-g)). Then the simple diffusion theory expression for 3D diffusion from a point source predicts the light distribution in the tissue. The influence of optical heterogeneities in the tissue can also be well approximated. A method is described for representing regions of increased absorption (such as a region with increased vascularity) as virtual sources of {"}negative radiant power{"} such that linear superposition of the true primary source and the virtual sources yields the net light distribution in the heterogeneous tissue. The method is rapid, flexible, and generally accurate to within about 15 % error. The method yields light distributions in optically complex tissues.",

author = "Jacques, {Steven L.} and Martin Ostermeyer and Lihong Wang and Andreas Hielscher",

note = "Funding Information: This work was supported by the Dept. of Energy (DE-FGO5-91ER617226) and the NIH Publisher Copyright: {\textcopyright} 1994 SPIE. All rights reserved.; Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III 1994 ; Conference date: 23-01-1994 Through 29-01-1994",

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AB - The paper considers rapid calculations of light distributions in a tissue for photodynamic therapy. The delivery system considered is a single optical fiber, although other configurations are easily modeled. The influence of optical heterogeneities in the tissue is considered. The optical distributions surrounding an optical fiber within a tissue can be well approximated by a point source of light placed one "reduced mean free path" (mfp') in front of the fiber tip. One mfp' equals 1/(μa + μs(1-g)). Then the simple diffusion theory expression for 3D diffusion from a point source predicts the light distribution in the tissue. The influence of optical heterogeneities in the tissue can also be well approximated. A method is described for representing regions of increased absorption (such as a region with increased vascularity) as virtual sources of "negative radiant power" such that linear superposition of the true primary source and the virtual sources yields the net light distribution in the heterogeneous tissue. The method is rapid, flexible, and generally accurate to within about 15 % error. The method yields light distributions in optically complex tissues.

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Light dosimetry in PDT using optical fiber delivery

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