Limitations and trade-offs in gene expression due to competition for shared cellular resources

Andras Gyorgy; Domitilla Del Vecchio

doi:10.1109/CDC.2014.7040238

Limitations and trade-offs in gene expression due to competition for shared cellular resources

Andras Gyorgy, Domitilla Del Vecchio

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Gene circuits share transcriptional and translational resources in the cell. The fact that these common resources are available only in limited amounts leads to unexpected couplings in protein expressions. As a result, our predictive ability of describing the behavior of gene circuits is limited. In this paper, we consider the simultaneous expression of proteins and describe the coupling among protein concentrations due to competition for RNA polymerase and ribosomes. In particular, we identify the limitations and trade-offs in gene expression by characterizing the attainable combinations of protein concentrations. We further present two application examples of our results: we show that even in the absence of regulatory linkages, genes can seemingly behave as repressors, and surprisingly, as activators to each other, purely due to the limited availability of shared cellular resources.

Original language	English (US)
Title of host publication	53rd IEEE Conference on Decision and Control,CDC 2014
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	5431-5436
Number of pages	6
Edition	February
ISBN (Electronic)	9781479977468
DOIs	https://doi.org/10.1109/CDC.2014.7040238
State	Published - 2014
Event	2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014 - Los Angeles, United States Duration: Dec 15 2014 → Dec 17 2014

Publication series

Name	Proceedings of the IEEE Conference on Decision and Control
Number	February
Volume	2015-February
ISSN (Print)	0743-1546
ISSN (Electronic)	2576-2370

Other

Other	2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014
Country/Territory	United States
City	Los Angeles
Period	12/15/14 → 12/17/14

ASJC Scopus subject areas

Control and Systems Engineering
Modeling and Simulation
Control and Optimization

Access to Document

10.1109/CDC.2014.7040238

Cite this

Gyorgy, A., & Del Vecchio, D. (2014). Limitations and trade-offs in gene expression due to competition for shared cellular resources. In 53rd IEEE Conference on Decision and Control,CDC 2014 (February ed., pp. 5431-5436). Article 7040238 (Proceedings of the IEEE Conference on Decision and Control; Vol. 2015-February, No. February). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CDC.2014.7040238

Limitations and trade-offs in gene expression due to competition for shared cellular resources. / Gyorgy, Andras; Del Vecchio, Domitilla.
53rd IEEE Conference on Decision and Control,CDC 2014. February. ed. Institute of Electrical and Electronics Engineers Inc., 2014. p. 5431-5436 7040238 (Proceedings of the IEEE Conference on Decision and Control; Vol. 2015-February, No. February).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gyorgy, A & Del Vecchio, D 2014, Limitations and trade-offs in gene expression due to competition for shared cellular resources. in 53rd IEEE Conference on Decision and Control,CDC 2014. February edn, 7040238, Proceedings of the IEEE Conference on Decision and Control, no. February, vol. 2015-February, Institute of Electrical and Electronics Engineers Inc., pp. 5431-5436, 2014 53rd IEEE Annual Conference on Decision and Control, CDC 2014, Los Angeles, United States, 12/15/14. https://doi.org/10.1109/CDC.2014.7040238

Gyorgy A, Del Vecchio D. Limitations and trade-offs in gene expression due to competition for shared cellular resources. In 53rd IEEE Conference on Decision and Control,CDC 2014. February ed. Institute of Electrical and Electronics Engineers Inc. 2014. p. 5431-5436. 7040238. (Proceedings of the IEEE Conference on Decision and Control; February). doi: 10.1109/CDC.2014.7040238

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Limitations and trade-offs in gene expression due to competition for shared cellular resources

Abstract

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