LINE-1 retrotransposons: Modulators of quantity and quality of mammalian gene expression?

Jeffrey S. Han, Jef D. Boeke

Research output: Contribution to journalReview articlepeer-review


LINE-1 (L1) retrotransposons are replicating repetitive elements that, by mass, are the most-abundant sequences in the human genome. Over one-third of mammalian genomes are the result, directly or indirectly, of L1 retrotransposition. L1 encodes two proteins: ORF1, an RNA-binding protein, and ORF2, an endonuclease/ reverse transcriptase. Both proteins are required for L1 mobilization. Apart from the obvious function of self-replication, it is not clear what other roles, if any, L1 plays within its host. The sheer magnitude of L1 sequences in our genome has fueled speculation that over evolutionary time L1 insertions may structurally modify endogenous genes and regulate gene expression. Here we provide a review of L1 replication and its potential functional consequences.

Original languageEnglish (US)
Pages (from-to)775-784
Number of pages10
Issue number8
StatePublished - Aug 2005

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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