Linker residues regulate the activity and stability of hexokinase 2, a promising anticancer target

Keyphrases

• Linker 100%
• Hexokinase 100%
• Anticancer Target 100%
• N-terminal Domain 33%
• Helix 16%
• Glucose Metabolism 16%
• Anticancer Therapeutics 16%
• In Cancer 8%
• Tumor 8%
• Tumor Progression 8%
• Hydrogen-deuterium Exchange 8%
• Tumor Initiation 8%
• Molecular Dynamics Simulation 8%
• Specific Inhibitor 8%
• Glycolysis 8%
• Cancer Growth 8%
• Selective Inhibition 8%
• Regulatory Site 8%
• Specific Inhibition 8%
• Isozymes 8%
• Elevated Glucose 8%
• Enhanced Dynamics 8%
• Non-active Site 8%

Biochemistry, Genetics and Molecular Biology

• Anticancer 100%
• Hexokinase 100%
• N-Terminus 41%
• Dynamics 16%
• C-Terminus 16%
• Glucose Metabolism 16%
• Tumor Progression 8%
• Enthalpy 8%
• Tumor Initiation 8%
• Upregulation 8%
• Regulatory Site 8%
• Isozyme 8%
• Hydrogen-Deuterium Exchange 8%
• HK1 8%