Linking dynamic patterns of neural activity in orbitofrontal cortex with decision making

Erin L. Rich, Frederic M. Stoll, Peter H. Rudebeck

Research output: Contribution to journalReview articlepeer-review

Abstract

Humans and animals demonstrate extraordinary flexibility in choice behavior, particularly when deciding based on subjective preferences. We evaluate options on different scales, deliberate, and often change our minds. Little is known about the neural mechanisms that underlie these dynamic aspects of decision-making, although neural activity in orbitofrontal cortex (OFC) likely plays a central role. Recent evidence from studies in macaques shows that attention modulates value responses in OFC, and that ensembles of OFC neurons dynamically signal different options during choices. When contexts change, these ensembles flexibly remap to encode the new task. Determining how these dynamic patterns emerge and relate to choices will inform models of decision-making and OFC function.

Original languageEnglish (US)
Pages (from-to)24-32
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume49
DOIs
StatePublished - Apr 2018

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Linking dynamic patterns of neural activity in orbitofrontal cortex with decision making'. Together they form a unique fingerprint.

Cite this