TY - JOUR
T1 - Lipid and lipoprotein levels remain stable in acute ischemic stroke
T2 - The Northern Manhattan Stroke Study
AU - Kargman, D. E.
AU - Tuck, C.
AU - Berglund, L.
AU - Lin, I. F.
AU - Mukherjee, R. S.
AU - Thompson, E. V.
AU - Jones, J.
AU - Boden-Albala, B.
AU - Paik, M. C.
AU - Sacco, R. L.
N1 - Funding Information:
We acknowledge the support of Drs J.P. Mohr, Director of Cerebrovascular Research and Henry N. Ginsberg, Director of the Irving Center for Clinical Research, in the Department of Medicine at Columbia University. This work was supported by grants from the National Institutes of Health, National Institute of Neurological Disorders and Stroke (Clinical Investigator Development Award KO8 NS 01782 and RO1 NS 29993) and the National Center for Research Resources (2 M01 RR00645). This work was also supported in part by a Grant-in Aid from the American Heart Association, New York City Affiliate. Dr Tuck is a GCRC-funded Clinical Associate Physician and Dr Berglund is a Florence Irving Associate Professor of Medicine and Established Scientist of the American Heart Association, New York City Affiliate. This work was presented in part in abstract form at the 22nd International Joint Conference on Stroke and Cerebral Circulation; Anaheim, California, February, 1997.
PY - 1998/8/4
Y1 - 1998/8/4
N2 - Serum lipoproteins including lipoprotein(a), Lp(a), are emerging as possible biological markers for cerebrovascular disease. Existing data on Lp(a) and serum lipids levels following acute ischemic stroke (AIS) are however equivocal. To determine whether serum Lp(a) and other lipid levels obtained within 24 h of acute ischemic stroke onset changed over the ensuing 4 weeks and whether these levels are related to an acute phase response, acquired nutritional deficiency, and neurovascular data, we conducted repeated measurement analyses among 19 subjects (mean age 65.0 ± 12.1 years; 32% women) presenting with AIS (evaluated within 9.7 ± 12.7 h). Eleven of the subjects had a moderate-to-severe stroke, defined by NIH stroke severity scale, and seven patients had a large cerebral infarction. Seven serial measurements of Lp(a), total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and other lipoproteins, major acute phase reactants and albumin levels were collected for each subject over 4 weeks. The mean initial levels, (mg/dl), of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, Lp(a), apolipoproteins A-I and B were: 22 ±57.6, 154 ± 56.0, 40 ± 10.4, 181 ± 93.7, 52 ± 28.6, 130 ± 24.6, and 141 ± 46.1, respectively. There were no significant changes in mean serum lipid, apolipoprotein or Lp(a) levels over the 4-week study period, analyzed by a random effects model to test for time trend. In addition, there were no significant changes in established acute phase or nutritional markers (C-reactive protein, alpha 1-glycoprotein, haptoglobin or serum albumin). Our findings suggest that serum lipid, apolipoprotein and Lp(a) levels remain stable following AIS, consistent with the absence of acute phase response or nutritional deficiency.
AB - Serum lipoproteins including lipoprotein(a), Lp(a), are emerging as possible biological markers for cerebrovascular disease. Existing data on Lp(a) and serum lipids levels following acute ischemic stroke (AIS) are however equivocal. To determine whether serum Lp(a) and other lipid levels obtained within 24 h of acute ischemic stroke onset changed over the ensuing 4 weeks and whether these levels are related to an acute phase response, acquired nutritional deficiency, and neurovascular data, we conducted repeated measurement analyses among 19 subjects (mean age 65.0 ± 12.1 years; 32% women) presenting with AIS (evaluated within 9.7 ± 12.7 h). Eleven of the subjects had a moderate-to-severe stroke, defined by NIH stroke severity scale, and seven patients had a large cerebral infarction. Seven serial measurements of Lp(a), total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, and other lipoproteins, major acute phase reactants and albumin levels were collected for each subject over 4 weeks. The mean initial levels, (mg/dl), of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, Lp(a), apolipoproteins A-I and B were: 22 ±57.6, 154 ± 56.0, 40 ± 10.4, 181 ± 93.7, 52 ± 28.6, 130 ± 24.6, and 141 ± 46.1, respectively. There were no significant changes in mean serum lipid, apolipoprotein or Lp(a) levels over the 4-week study period, analyzed by a random effects model to test for time trend. In addition, there were no significant changes in established acute phase or nutritional markers (C-reactive protein, alpha 1-glycoprotein, haptoglobin or serum albumin). Our findings suggest that serum lipid, apolipoprotein and Lp(a) levels remain stable following AIS, consistent with the absence of acute phase response or nutritional deficiency.
KW - Acute phase reactants
KW - Lipids
KW - Lipoprotein(a)
KW - Stroke
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U2 - 10.1016/S0021-9150(98)00085-9
DO - 10.1016/S0021-9150(98)00085-9
M3 - Article
C2 - 9712347
AN - SCOPUS:0031859239
SN - 0021-9150
VL - 139
SP - 391
EP - 399
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -