LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

Wanxu Huang, Hua Li, Qingsong Yu, Wei Xiao, Dan Ohtan Wang

Research output: Contribution to journalReview articlepeer-review


DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-specific DNA methylation patterns established or disturbed is a pivotal question in developmental biology and cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates DNA methylation in both physiological and pathological conditions. In this review, we provide an overview of the current understanding of lncRNA-mediated DNA methylation, with emphasis on the roles of this mechanism in cancer, which to the best of our knowledge, has not been systematically summarized. In addition, we also discuss the potential clinical applications of this mechanism in RNA-targeting drug development.

Original languageEnglish (US)
Article number100
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
StatePublished - Dec 2022


  • Cancer
  • DNA methylation
  • DNMT
  • lncRNA
  • Non-coding RNA
  • TET

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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