Local delivery of adenosine receptor agonists to promote bone regeneration and defect healing

Christopher D. Lopez, Jonathan M. Bekisz, Carmen Corciulo, Aranzazu Mediero, Paulo G. Coelho, Lukasz Witek, Roberto L. Flores, Bruce N. Cronstein

Research output: Contribution to journalReview article


Adenosine receptor activation has been investigated as a potential therapeutic approach to heal bone. Bone has enhanced regenerative potential when influenced by either direct or indirect adenosine receptor agonism. As investigators continue to elucidate how adenosine influences bone cell homeostasis at the cellular and molecular levels, a small but growing body of literature has reported successful in vivo applications of adenosine delivery. This review summarizes the role adenosine receptor ligation plays in osteoblast and osteoclast biology and remodeling/regeneration. It also reports on all the modalities described in the literature at this point for delivery of adenosine through in vivo models for bone healing and regeneration.

Original languageEnglish (US)
Pages (from-to)240-247
Number of pages8
JournalAdvanced Drug Delivery Reviews
StatePublished - Jun 2019



  • Adenosine receptor
  • Bone regeneration
  • Osteoblast
  • Osteoclast
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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