Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes

Bo Wang, Katie A. Lucy, Joel S. Schuman, Hiroshi Ishikawa, Richard A. Bilonick, Ian A. Sigal, Larry Kagemann, Chen Lu, James G. Fujimoto, Gadi Wollstein

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT). The CRVT location was manually delineated in separate projection images of the LC and prelamina. We found that the CRVT in glaucoma suspect and glaucomatous eyes was located significantly more nasally compared to healthy eyes at the level of the prelamina. There was no detectable difference found in the location of the CRVT at the level of the LC between diagnostic groups. While the nasal location of the CRVT in the prelamina has been associated with glaucomatous axonal death, our results suggest that the CRVT in the LC is anchored in the tissue with minimal variation in glaucomatous eyes.

    Original languageEnglish (US)
    Article number9930
    JournalScientific reports
    Volume7
    Issue number1
    DOIs
    StatePublished - Dec 1 2017

    ASJC Scopus subject areas

    • General

    Fingerprint Dive into the research topics of 'Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes'. Together they form a unique fingerprint.

    Cite this