Logical computation using algorithmic self-assembly of DNA triple-crossover molecules

Chengde Mao, Thomas H. LaBean, John H. Reif, Nadrian C. Seeman

Research output: Contribution to journalArticle

Abstract

Recent work has demonstrated the self-assembly of designed periodic two-dimensional arrays composed of DNA tiles, in which the intermolecular contacts are directed by 'sticky' ends. In a mathematical context, aperiodic mosaics may be formed by the self-assembly of 'Wang' tiles, a process that emulates the operation of a Turing machine. Macroscopic self-assembly has been used to perform computations; there is also a logical equivalence between DNA sticky ends and Wang tile edges. This suggests that the self-assembly of DNA-based tiles could be used to perform DNA-based computation. Algorithmic aperiodic self-assembly requires greater fidelity than periodic self-assembly, because correct tiles must compete with partially correct tiles. Here we report a one-dimensional algorithmic self-assembly of DNA triple-crossover molecules that can be used to execute four steps of a logical (cumulative XOR) operation on a string of binary bits.

Original languageEnglish (US)
Pages (from-to)493-496
Number of pages4
JournalNature
Volume407
Issue number6803
DOIs
StatePublished - Sep 28 2000

ASJC Scopus subject areas

  • General

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