Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers

V. Saxena; M. Sadoqi; S. Kumar; J. Shao

doi:10.1117/12.534336

Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers

V. Saxena, M. Sadoqi, S. Kumar, J. Shao

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Indocyanine green (ICG) is a near-infrared fluorescence contrast agent, which has enormous potential in early tumor diagnosis and therapy. The objective of this study is to develop biodegradable nanoparticles entrapping ICG and to characterize its intracellular uptake and photodynamic activity in different cancer cell lines. Nanoparticles entrapping ICG were engineered, characterized and the intracellular uptake of ICG was investigated in B16-F10 and C-33A cancer cell lines. The photodynamic activity of ICG-loaded nanoparticles was also investigated. The nanoparticles enhanced the intracellular uptake of ICG and showed significant photodynamic activity, especially at very low ICG concentrations. These preliminary studies indicate the potential of efficient tumor cell delivery and tumoricidal effect of ICG when incorporated in nanoparticles.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	K.E. Bartels, L.S. Bass, W.T.W. Riese, K.W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S.J. Madsen, R.S. Malek
Pages	41-46
Number of pages	6
Volume	5
Edition	1
DOIs	https://doi.org/10.1117/12.534336
State	Published - 2004
Event	Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV - San Jose, CA, United States Duration: Jan 24 2004 → Jan 27 2004

Other

Other	Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV
Country/Territory	United States
City	San Jose, CA
Period	1/24/04 → 1/27/04

Keywords

Fluorescence
Indocyanine green
Intracellular uptake
Nanoparticles
Photodynamic therapy
PLGA

ASJC Scopus subject areas

Engineering(all)

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10.1117/12.534336

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Saxena, V., Sadoqi, M., Kumar, S., & Shao, J. (2004). Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. In K. E. Bartels, L. S. Bass, W. T. W. Riese, K. W. Gregory, H. Hirschberg, A. Katzir, N. Kollias, S. J. Madsen, & R. S. Malek (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (1 ed., Vol. 5, pp. 41-46). Article 09 https://doi.org/10.1117/12.534336

Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. / Saxena, V.; Sadoqi, M.; Kumar, S. et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / K.E. Bartels; L.S. Bass; W.T.W. Riese; K.W. Gregory; H. Hirschberg; A. Katzir; N. Kollias; S.J. Madsen; R.S. Malek. Vol. 5 1. ed. 2004. p. 41-46 09.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Saxena, V, Sadoqi, M, Kumar, S & Shao, J 2004, Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. in KE Bartels, LS Bass, WTW Riese, KW Gregory, H Hirschberg, A Katzir, N Kollias, SJ Madsen & RS Malek (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 1 edn, vol. 5, 09, pp. 41-46, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XIV, San Jose, CA, United States, 1/24/04. https://doi.org/10.1117/12.534336

Saxena V, Sadoqi M, Kumar S, Shao J. Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. In Bartels KE, Bass LS, Riese WTW, Gregory KW, Hirschberg H, Katzir A, Kollias N, Madsen SJ, Malek RS, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 1 ed. Vol. 5. 2004. p. 41-46. 09 doi: 10.1117/12.534336

Saxena, V. ; Sadoqi, M. ; Kumar, S. et al. / Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. editor / K.E. Bartels ; L.S. Bass ; W.T.W. Riese ; K.W. Gregory ; H. Hirschberg ; A. Katzir ; N. Kollias ; S.J. Madsen ; R.S. Malek. Vol. 5 1. ed. 2004. pp. 41-46

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Long circulating near infrared fluorescent nanoparticles for diagnosis and photodynamic therapy of cutaneous cancers

Abstract

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Keywords

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