Long lived NMR signal in bone

Boyang Zhang, Jae Seung Lee, Anatoly Khitrin, Alexej Jerschow

Research output: Contribution to journalArticlepeer-review


Solids and rigid tissues, such as bone, ligaments, and tendons, typically appear dark in MRI, which is due to the extremely short-lived proton nuclear magnetic resonance signals. This short lifetime is due to strong dipolar interactions between immobilized proton spins, which render it challenging to detect these signals with sufficient resolution and sensitivity. Here we show the possibility of exciting long-lived signals in cortical bone tissue with a signature consistent with that of bound water signals. It is further shown that dipolar coupling networks are an integral requirement for the excitation of these long-lived signals. The use of these signals could enhance the ability to visualize rigid tissues and solid samples with high resolution and sensitivity via MRI.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalJournal of Magnetic Resonance
StatePublished - Jun 2013


  • Bone
  • Dipolar coupling
  • Homogeneous broadening
  • Long-lived signals
  • MRI

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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