Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

A. Rullo; A. Reiner; A. Reiter; D. Trauner; E. Y. Isacoff; G. A. Woolley

doi:10.1039/c4cc06612j

Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

A. Rullo, A. Reiner, A. Reiter, D. Trauner, E. Y. Isacoff, G. A. Woolley

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

Original language	English (US)
Pages (from-to)	14613-14615
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	93
DOIs	https://doi.org/10.1039/c4cc06612j
State	Published - Oct 28 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c4cc06612j

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abstract = "A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.",

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AU - Trauner, D.

AU - Isacoff, E. Y.

AU - Woolley, G. A.

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AB - A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.

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Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative

Abstract

ASJC Scopus subject areas

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