TY - GEN
T1 - Longitudinal growth modeling of discrete-time functions with application to DTI tract evolution in early neurodevelopment
AU - Sharma, Anuja
AU - Durrleman, Stanley
AU - Gilmore, John H.
AU - Gerig, Guido
PY - 2012
Y1 - 2012
N2 - We present a new framework for spatiotemporal analysis of parameterized functions attributed by properties of 4D longitudinal image data. Our driving application is the measurement of temporal change in white matter diffusivity of fiber tracts. A smooth temporal modeling of change from a discrete-time set of functions is obtained with an extension of the logistic growth model to time-dependent spline functions, capturing growth with only a few descriptive parameters. An unbiased template baseline function is also jointly estimated. Solution is demonstrated via energy minimization with an extension to simultaneous modeling of trajectories for multiple subjects. The new framework is validated with synthetic data and applied to longitudinal DTI from 15 infants. Interpretation of estimated model growth parameters is facilitated by visualization in the original coordinate space of fiber tracts.
AB - We present a new framework for spatiotemporal analysis of parameterized functions attributed by properties of 4D longitudinal image data. Our driving application is the measurement of temporal change in white matter diffusivity of fiber tracts. A smooth temporal modeling of change from a discrete-time set of functions is obtained with an extension of the logistic growth model to time-dependent spline functions, capturing growth with only a few descriptive parameters. An unbiased template baseline function is also jointly estimated. Solution is demonstrated via energy minimization with an extension to simultaneous modeling of trajectories for multiple subjects. The new framework is validated with synthetic data and applied to longitudinal DTI from 15 infants. Interpretation of estimated model growth parameters is facilitated by visualization in the original coordinate space of fiber tracts.
KW - diffusion tensor imaging
KW - early brain developming
KW - growth functions
KW - longitudinal image data
KW - spatiotemporal modeling
UR - http://www.scopus.com/inward/record.url?scp=84864829875&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864829875&partnerID=8YFLogxK
U2 - 10.1109/ISBI.2012.6235829
DO - 10.1109/ISBI.2012.6235829
M3 - Conference contribution
AN - SCOPUS:84864829875
SN - 9781457718588
T3 - Proceedings - International Symposium on Biomedical Imaging
SP - 1397
EP - 1400
BT - 2012 9th IEEE International Symposium on Biomedical Imaging
T2 - 2012 9th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2012
Y2 - 2 May 2012 through 5 May 2012
ER -