Loss of 5-HT1A receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone

Baolang Liao, Barbara Miesak, Efrain C. Azmitia

Research output: Contribution to journalArticle

Abstract

Two months after bilateral adrenalectomy, 5-HT1A receptor mRNA labelling was decreased in the granular cell layer of the dentate gyrus but not in the pyramidal cell layer of Ammon's horn. Two month adrenalectomized rats given dexamethasone (10 υg/ml saline) 24 or 72 h before perfusion showed a progressive recovery in 5-HT1A mRNA labelling in the dentate gyrus. 5-HT1A expression may underlie hippocampal neuronal plasticity after long-term adrenalectomy.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalMolecular Brain Research
Volume19
Issue number4
DOIs
StatePublished - Sep 1993

Keywords

  • Ammon's horn
  • Degeneration
  • Deoxyoligonucleotide probe
  • Glucocorticoid
  • Hippocampus
  • In situ hybridization
  • Nissl stain

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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