Loss of 5-HT1A receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone

Baolang Liao; Barbara Miesak; Efrain C. Azmitia

doi:10.1016/0169-328X(93)90134-B

Loss of 5-HT_1A receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone

Baolang Liao, Barbara Miesak, Efrain C. Azmitia

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Two months after bilateral adrenalectomy, 5-HT_1A receptor mRNA labelling was decreased in the granular cell layer of the dentate gyrus but not in the pyramidal cell layer of Ammon's horn. Two month adrenalectomized rats given dexamethasone (10 υg/ml saline) 24 or 72 h before perfusion showed a progressive recovery in 5-HT_1A mRNA labelling in the dentate gyrus. 5-HT_1A expression may underlie hippocampal neuronal plasticity after long-term adrenalectomy.

Original language	English (US)
Pages (from-to)	328-332
Number of pages	5
Journal	Molecular Brain Research
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/0169-328X(93)90134-B
State	Published - Sep 1993

Keywords

Ammon's horn
Degeneration
Deoxyoligonucleotide probe
Glucocorticoid
Hippocampus
In situ hybridization
Nissl stain

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0169-328X(93)90134-B

Cite this

@article{ea0429b353aa435f9ac12d34cfd1d162,

title = "Loss of 5-HT1A receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone",

abstract = "Two months after bilateral adrenalectomy, 5-HT1A receptor mRNA labelling was decreased in the granular cell layer of the dentate gyrus but not in the pyramidal cell layer of Ammon's horn. Two month adrenalectomized rats given dexamethasone (10 υg/ml saline) 24 or 72 h before perfusion showed a progressive recovery in 5-HT1A mRNA labelling in the dentate gyrus. 5-HT1A expression may underlie hippocampal neuronal plasticity after long-term adrenalectomy.",

keywords = "Ammon's horn, Degeneration, Deoxyoligonucleotide probe, Glucocorticoid, Hippocampus, In situ hybridization, Nissl stain",

author = "Baolang Liao and Barbara Miesak and Azmitia, {Efrain C.}",

year = "1993",

month = sep,

doi = "10.1016/0169-328X(93)90134-B",

language = "English (US)",

volume = "19",

pages = "328--332",

journal = "Molecular Brain Research",

issn = "0169-328X",

publisher = "Elsevier",

number = "4",

}

TY - JOUR

T1 - Loss of 5-HT1A receptor mRNA in the dentate gyrus of the long-term adrenalectomized rats and rapid reversal by dexamethasone

AU - Liao, Baolang

AU - Miesak, Barbara

AU - Azmitia, Efrain C.

PY - 1993/9

Y1 - 1993/9

N2 - Two months after bilateral adrenalectomy, 5-HT1A receptor mRNA labelling was decreased in the granular cell layer of the dentate gyrus but not in the pyramidal cell layer of Ammon's horn. Two month adrenalectomized rats given dexamethasone (10 υg/ml saline) 24 or 72 h before perfusion showed a progressive recovery in 5-HT1A mRNA labelling in the dentate gyrus. 5-HT1A expression may underlie hippocampal neuronal plasticity after long-term adrenalectomy.

AB - Two months after bilateral adrenalectomy, 5-HT1A receptor mRNA labelling was decreased in the granular cell layer of the dentate gyrus but not in the pyramidal cell layer of Ammon's horn. Two month adrenalectomized rats given dexamethasone (10 υg/ml saline) 24 or 72 h before perfusion showed a progressive recovery in 5-HT1A mRNA labelling in the dentate gyrus. 5-HT1A expression may underlie hippocampal neuronal plasticity after long-term adrenalectomy.

KW - Ammon's horn

KW - Degeneration

KW - Deoxyoligonucleotide probe

KW - Glucocorticoid

KW - Hippocampus

KW - In situ hybridization

KW - Nissl stain

UR - http://www.scopus.com/inward/record.url?scp=0027219344&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027219344&partnerID=8YFLogxK

U2 - 10.1016/0169-328X(93)90134-B

DO - 10.1016/0169-328X(93)90134-B

M3 - Article

C2 - 8231736

AN - SCOPUS:0027219344

SN - 0169-328X

VL - 19

SP - 328

EP - 332

JO - Molecular Brain Research

JF - Molecular Brain Research

IS - 4

ER -