Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

Liyuan Ran; Xiaoshuang Wang; Ai Mi; Yanshuang Liu; Jin Wu; Haoan Wang; Meihua Guo; Jie Sun; Bo Liu; Youwei Li; Dan Wang; Rujiao Jiang; Ning Wang; Wenting Gao; Li Zeng; Lin Huang; Xiaoli Chen; Derek LeRoith; Bin Liang; Xin Li; Yingjie Wu

doi:10.1016/j.isci.2019.05.020

Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

Liyuan Ran, Xiaoshuang Wang, Ai Mi, Yanshuang Liu, Jin Wu, Haoan Wang, Meihua Guo, Jie Sun, Bo Liu, Youwei Li, Dan Wang, Rujiao Jiang, Ning Wang, Wenting Gao, Li Zeng, Lin Huang, Xiaoli Chen, Derek LeRoith, Bin Liang, Xin LiYingjie Wu

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Physiology;

Original language	English (US)
Pages (from-to)	106-121
Number of pages	16
Journal	iScience
Volume	16
DOIs	https://doi.org/10.1016/j.isci.2019.05.020
State	Published - Jun 28 2019

Keywords

Cellular Physiology
Diabetology
Endocrinology
Physiology

ASJC Scopus subject areas

General

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10.1016/j.isci.2019.05.020

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Ran, L., Wang, X., Mi, A., Liu, Y., Wu, J., Wang, H., Guo, M., Sun, J., Liu, B., Li, Y., Wang, D., Jiang, R., Wang, N., Gao, W., Zeng, L., Huang, L., Chen, X., LeRoith, D., Liang, B., ... Wu, Y. (2019). Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis. iScience, 16, 106-121. https://doi.org/10.1016/j.isci.2019.05.020

Ran, L, Wang, X, Mi, A, Liu, Y, Wu, J, Wang, H, Guo, M, Sun, J, Liu, B, Li, Y, Wang, D, Jiang, R, Wang, N, Gao, W, Zeng, L, Huang, L, Chen, X, LeRoith, D, Liang, B, Li, X & Wu, Y 2019, 'Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis', iScience, vol. 16, pp. 106-121. https://doi.org/10.1016/j.isci.2019.05.020

@article{c128e5fec97f481887a78c6bef889bb0,

title = "Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis",

abstract = "Physiology;",

keywords = "Cellular Physiology, Diabetology, Endocrinology, Physiology",

author = "Liyuan Ran and Xiaoshuang Wang and Ai Mi and Yanshuang Liu and Jin Wu and Haoan Wang and Meihua Guo and Jie Sun and Bo Liu and Youwei Li and Dan Wang and Rujiao Jiang and Ning Wang and Wenting Gao and Li Zeng and Lin Huang and Xiaoli Chen and Derek LeRoith and Bin Liang and Xin Li and Yingjie Wu",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81600668 ; No. 81471000l ); the Ministry of Science and Technology of China (No. 2014DFA32120 ); and Research Project of Educational Commission of Liaoning , China (No. L2016023 ). Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81600668; No. 81471000l); the Ministry of Science and Technology of China (No. 2014DFA32120); and Research Project of Educational Commission of Liaoning, China (No.L2016023). Y.W. and L.R. conceived the study, designed the experiments, and wrote the manuscript. L.R. and X.W. performed experiments and collected and analyzed data. A.M. Y.L. and H.W. performed cold and cell experiments. J.W. J.S. and B.L. assisted with the qPCR and western Blot. M.G. D.W. W.G. and Y.L. performed animal breeding. R.J. and N.W. assisted with histological experiments. L.Z. L.H. X.C. B.L. and X.L. also designed the experiments and involved in discussion and writing the manuscript. L.Z. D.L. and X.L. provided language help. All authors reviewed the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = jun,

day = "28",

doi = "10.1016/j.isci.2019.05.020",

language = "English (US)",

volume = "16",

pages = "106--121",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

AU - Ran, Liyuan

AU - Wang, Xiaoshuang

AU - Mi, Ai

AU - Liu, Yanshuang

AU - Wu, Jin

AU - Wang, Haoan

AU - Guo, Meihua

AU - Sun, Jie

AU - Liu, Bo

AU - Li, Youwei

AU - Wang, Dan

AU - Jiang, Rujiao

AU - Wang, Ning

AU - Gao, Wenting

AU - Zeng, Li

AU - Huang, Lin

AU - Chen, Xiaoli

AU - LeRoith, Derek

AU - Liang, Bin

AU - Li, Xin

AU - Wu, Yingjie

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81600668 ; No. 81471000l ); the Ministry of Science and Technology of China (No. 2014DFA32120 ); and Research Project of Educational Commission of Liaoning , China (No. L2016023 ). Funding Information: This work was supported by the National Natural Science Foundation of China (No. 81600668; No. 81471000l); the Ministry of Science and Technology of China (No. 2014DFA32120); and Research Project of Educational Commission of Liaoning, China (No.L2016023). Y.W. and L.R. conceived the study, designed the experiments, and wrote the manuscript. L.R. and X.W. performed experiments and collected and analyzed data. A.M. Y.L. and H.W. performed cold and cell experiments. J.W. J.S. and B.L. assisted with the qPCR and western Blot. M.G. D.W. W.G. and Y.L. performed animal breeding. R.J. and N.W. assisted with histological experiments. L.Z. L.H. X.C. B.L. and X.L. also designed the experiments and involved in discussion and writing the manuscript. L.Z. D.L. and X.L. provided language help. All authors reviewed the manuscript. The authors declare no competing interests. Publisher Copyright: © 2019 The Author(s)

PY - 2019/6/28

Y1 - 2019/6/28

N2 - Physiology;

AB - Physiology;

KW - Cellular Physiology

KW - Diabetology

KW - Endocrinology

KW - Physiology

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U2 - 10.1016/j.isci.2019.05.020

DO - 10.1016/j.isci.2019.05.020

M3 - Article

AN - SCOPUS:85066277807

SN - 2589-0042

VL - 16

SP - 106

EP - 121

JO - iScience

JF - iScience

ER -

Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

Abstract

Keywords

ASJC Scopus subject areas

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