TY - JOUR
T1 - Low levels of mercury inhibit the respiratory burst in human polymorphonuclear leukocytes
AU - Malamud, Daniel
AU - Dietrich, Scott A.
AU - Shapiro, Irving M.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1985/5/16
Y1 - 1985/5/16
N2 - The objective of this investigation was to examine the effects of low levels of Hg(II) on the respiratory burst of PMNs by monitoring O2 consumption, superoxide radical formation, and chemiluminescence. Hg(II) at concentration of 10-100 ng/ml profoundly inhibited zymosan-stimulated human cells. This inhibition was immediate in onset and occurred with minimal loss of cell viability. Effects of Hg(II) on the PMN respiratory burst were compared with those of Sn, Pb, Se, Au, Ag and Cu. Only in the case of Ag and Cu did the inhibitory effects approach those of Hg. The results indicate that Hg(II) may serve as a specific inhibitor of components of the respiratory burst.
AB - The objective of this investigation was to examine the effects of low levels of Hg(II) on the respiratory burst of PMNs by monitoring O2 consumption, superoxide radical formation, and chemiluminescence. Hg(II) at concentration of 10-100 ng/ml profoundly inhibited zymosan-stimulated human cells. This inhibition was immediate in onset and occurred with minimal loss of cell viability. Effects of Hg(II) on the PMN respiratory burst were compared with those of Sn, Pb, Se, Au, Ag and Cu. Only in the case of Ag and Cu did the inhibitory effects approach those of Hg. The results indicate that Hg(II) may serve as a specific inhibitor of components of the respiratory burst.
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U2 - 10.1016/0006-291X(85)91060-5
DO - 10.1016/0006-291X(85)91060-5
M3 - Article
C2 - 2988529
AN - SCOPUS:0021799734
SN - 0006-291X
VL - 128
SP - 1145
EP - 1151
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -