TY - JOUR
T1 - Low-power suppression of fast-motion spin 3/2 signals
AU - Nimerovsky, Evgeny
AU - Ilott, Andrew J.
AU - Jerschow, Alexej
N1 - Funding Information:
The Bruker Avance – 500 NMR Spectrometer was acquired through the support of the U.S. National Science Foundation under Award Number CHE 01162222 . We acknowledge funding from the U.S. National Science Foundation , award No. CHE 1412064 for methodology development, and NIH R01AR060238 and NIH R01EB016045 for imaging-related work.
Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.
AB - Triple Quantum Filters (TQFs) are frequently used for the selection of bi-exponentially relaxing spin 3/2 nuclei (in particular 23Na) in ordered environments, such as biological tissues. These methods provide an excellent selection of slow-motion spins, but their sensitivity is generally low, and coherence selection requirements may lead to long experiments when applied in vivo. Alternative methods, such as 2P DIM, have demonstrated that the sensitivities of the signals from bi-exponentially relaxing sodium can be significantly increased using strategies other than TQFs. A shortcoming of the 2P DIM method is its strong dependence on B0 inhomogeneities. We describe here a method, which is sensitive to the slow-motion regime, while the signal from spins in the fast-motion regime is suppressed. This method is shown to be more effective than TQFs, requires minimal phase cycling for the suppression of the influence of rf inhomogeneity, and has less dependence on resonance offsets and B0-inhomogeneity than 2P DIM.
KW - Bi-exponential relaxation
KW - Slow-motion sodium
KW - Sodium NMR
KW - Weak radio-frequency fields
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U2 - 10.1016/j.jmr.2016.09.007
DO - 10.1016/j.jmr.2016.09.007
M3 - Article
C2 - 27689532
AN - SCOPUS:84988876270
VL - 272
SP - 129
EP - 140
JO - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
SN - 1090-7807
ER -