TY - JOUR
T1 - Lower extremity MRI following 10-week supervised exercise intervention in patients with diabetic peripheral neuropathy
AU - Brown, Ryan
AU - Sharafi, Azadeh
AU - Slade, Jill M.
AU - Convit, Antonio
AU - Davis, Nathan
AU - Baete, Steven
AU - Milton, Heather
AU - Mroczek, Kenneth J.
AU - Kluding, Patricia M.
AU - Regatte, Ravinder R.
AU - Parasoglou, Prodromos
AU - Rao, Smita
N1 - Funding Information:
Contributors PP and SR conceptualized the study. AS, ND, SB, SR, and RB curated and analyzed the data. PP, SR, RRR, and RB acquired financial support for the project. AS, SR, HM, and RB conducted the experiments. PP, JMS, AS, SB, RRR, and RB designed the MRI protocol. SR and PMK designed the 10-week intervention program. SR and RB administered and supervised the study. AC and KJM assisted with patient recruitment. AS, SB, PP, RRR, and RB developed MRI software. All authors wrote and edited the manuscript. RB is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Publisher Copyright:
©
PY - 2021/9/13
Y1 - 2021/9/13
N2 - Introduction The purpose of this study was to characterize using MRI the effects of a 10-week supervised exercise program on lower extremity skeletal muscle composition, nerve microarchitecture, and metabolic function in individuals with diabetic peripheral neuropathy (DPN). Research design and methods Twenty participants with DPN completed a longitudinal trial consisting of a 30-day control period, during which subjects made no change to their lifestyle, followed by a 10-week intervention program that included three supervised aerobic and resistance exercise sessions per week targeting the upper and lower extremities. The participants' midcalves were scanned with multinuclear MRI two times prior to intervention (baseline 1 and baseline 2) and once following intervention to measure relaxation times (T1, T1ρ, and T2), phosphocreatine recovery, fat fraction, and diffusion parameters. Results There were no changes between baseline 1 and baseline 2 MRI metrics (p>0.2). Significant changes (p<0.05) between baseline 2 and postintervention MRI metrics were: gastrocnemius medialis (GM) T1 -2.3%±3.0% and soleus T2 -3.2%±3.1%. Trends toward significant changes (0.050.3) and tibial nerve fractional anisotropy (p>0.6) and apparent diffusion coefficient (p>0.4). Conclusions The 10-week supervised exercise intervention program successfully reduced adiposity and altered resting tissue properties in the lower leg in DPN. Gastrocnemius mitochondrial oxidative capacity and tibial nerve microarchitecture changes were not observed, either due to lack of response to therapy or to lack of measurement sensitivity.
AB - Introduction The purpose of this study was to characterize using MRI the effects of a 10-week supervised exercise program on lower extremity skeletal muscle composition, nerve microarchitecture, and metabolic function in individuals with diabetic peripheral neuropathy (DPN). Research design and methods Twenty participants with DPN completed a longitudinal trial consisting of a 30-day control period, during which subjects made no change to their lifestyle, followed by a 10-week intervention program that included three supervised aerobic and resistance exercise sessions per week targeting the upper and lower extremities. The participants' midcalves were scanned with multinuclear MRI two times prior to intervention (baseline 1 and baseline 2) and once following intervention to measure relaxation times (T1, T1ρ, and T2), phosphocreatine recovery, fat fraction, and diffusion parameters. Results There were no changes between baseline 1 and baseline 2 MRI metrics (p>0.2). Significant changes (p<0.05) between baseline 2 and postintervention MRI metrics were: gastrocnemius medialis (GM) T1 -2.3%±3.0% and soleus T2 -3.2%±3.1%. Trends toward significant changes (0.050.3) and tibial nerve fractional anisotropy (p>0.6) and apparent diffusion coefficient (p>0.4). Conclusions The 10-week supervised exercise intervention program successfully reduced adiposity and altered resting tissue properties in the lower leg in DPN. Gastrocnemius mitochondrial oxidative capacity and tibial nerve microarchitecture changes were not observed, either due to lack of response to therapy or to lack of measurement sensitivity.
KW - MRI
KW - exercise
KW - intervention
KW - lower extremity
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U2 - 10.1136/bmjdrc-2021-002312
DO - 10.1136/bmjdrc-2021-002312
M3 - Article
C2 - 34518157
AN - SCOPUS:85115071248
SN - 2052-4897
VL - 9
JO - BMJ Open Diabetes Research and Care
JF - BMJ Open Diabetes Research and Care
IS - 1
M1 - e002312
ER -