Machine-to-Machine (M2M) communication is one of the emerging fields today and expected to play a major role in interconnecting various types of devices for different applications, such as logistics. Mobile communication standards, such as Long Term Evolution Advanced (LTE-A), have high data rate capability and are designed to provide broadband services to the human-based communication. M2M devices in logistics usually transmit small amount of data depending on the application scenario. LTE-A can be optimized to provide better performance of M2M devices in logistics. This paper studies a Relay Node (RN) based solution in LTE-A to integrate M2M devices in mobile cellular networks. Different M2M scenarios are developed for logistics along with normal LTE-A users in our LTE-A simulation model implemented in OPNET Modeler. The simulation results show that the data traffic performance of LTE-A network improves significantly if RN is utilized for aggregation and multiplexing of M2M data traffic in logistics.