TY - JOUR
T1 - Magnetoencephalographic spectral fingerprints differentiate evidence accumulation from saccadic motor preparation in perceptual decision-making
AU - D'Andrea, Antea
AU - Basti, Alessio
AU - Tosoni, Annalisa
AU - Guidotti, Roberto
AU - Chella, Federico
AU - Michelmann, Sebastian
AU - Romani, Gian Luca
AU - Pizzella, Vittorio
AU - Marzetti, Laura
N1 - Funding Information:
This study was funded by the European Research Council (ERC Synergy) under the European Union’s Horizon 2020 research and innovation programme (ConnectToBrain; grant agreement No. 810377 ). The content of this article reflects only the authors’ view and the ERC Executive Agency is not responsible for the content. Author L.M. was also supported by Bial Foundation grant numbers 66/16 and 80/20 .
Funding Information:
This study was funded by the European Research Council (ERC Synergy) under the European Union's Horizon 2020 research and innovation programme (ConnectToBrain; grant agreement No. 810377). The content of this article reflects only the authors’ view and the ERC Executive Agency is not responsible for the content. Author L.M. was also supported by Bial Foundation grant numbers 66/16 and 80/20. A.D.A.: Conceptualization, investigation, formal analysis, writing - original draft, visualization; A.B.: methodology, software, formal analysis, visualization; A.T.: Conceptualization, writing - original draft, writing - review & editing; R.G.: software, visualization, writing - review & editing; F.C.: software, formal analysis; S.M.: writing - original draft, writing - review & editing; G.L.R.: funding acquisition, writing - review & editing; V.P.: methodology, writing - original draft, writing - review & editing; L.M.: methodology, writing - original draft, writing - review & editing, supervision. The authors declare no conflicts of interest. We support inclusive, diverse, and equitable conduct of research.
Publisher Copyright:
© 2022 The Authors
PY - 2022/10/21
Y1 - 2022/10/21
N2 - The understanding of the neurobiological basis of perceptual decision-making has been profoundly shaped by studies in the monkey brain in tandem with mathematical models, providing the basis for the formulation of an intentional account of decision-making. Although much progress has been made in human studies, a characterization of the neural underpinnings of an integrative mechanism, where evidence accumulation and the selection and execution of responses are carried out by the same system, remains challenging. Here, by employing magnetoencephalographic recording in combination with an experimental protocol that measures saccadic response and leverages a systematic modulation of evidence levels, we obtained a spectral dissociation between evidence accumulation mechanisms and motor preparation within the same brain region. Specifically, we show that within the dorsomedial parietal cortex alpha power modulation reflects the amount of sensory evidence available while beta power modulations reflect motor preparation, putatively representing the human homolog of the saccadic-related LIP region.
AB - The understanding of the neurobiological basis of perceptual decision-making has been profoundly shaped by studies in the monkey brain in tandem with mathematical models, providing the basis for the formulation of an intentional account of decision-making. Although much progress has been made in human studies, a characterization of the neural underpinnings of an integrative mechanism, where evidence accumulation and the selection and execution of responses are carried out by the same system, remains challenging. Here, by employing magnetoencephalographic recording in combination with an experimental protocol that measures saccadic response and leverages a systematic modulation of evidence levels, we obtained a spectral dissociation between evidence accumulation mechanisms and motor preparation within the same brain region. Specifically, we show that within the dorsomedial parietal cortex alpha power modulation reflects the amount of sensory evidence available while beta power modulations reflect motor preparation, putatively representing the human homolog of the saccadic-related LIP region.
KW - Biological sciences
KW - Neuroscience
KW - Sensory neuroscience
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U2 - 10.1016/j.isci.2022.105246
DO - 10.1016/j.isci.2022.105246
M3 - Article
AN - SCOPUS:85139866482
SN - 2589-0042
VL - 25
JO - iScience
JF - iScience
IS - 10
M1 - 105246
ER -