Maintaining a stochastic neuronal cell fate decision

Daniel Vasiliauskas, Robert Johnston, Claude Desplan

Research output: Contribution to journalReview article

Abstract

Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcription factor, NSY-7, that acts to stabilize a stochastic subtype choice in AWC chemo- sensory neurons in Caenorhabditis elegans.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalGenes and Development
Volume23
Issue number4
DOIs
StatePublished - Feb 15 2009

Keywords

  • ; activity-dependent gene expression
  • Homeodomain
  • Olfactory development
  • Transcriptional maintenance
  • Transcriptional repression
  • cGMP-dependent protein kinase

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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