Maintaining a stochastic neuronal cell fate decision

Daniel Vasiliauskas; Robert Johnston; Claude Desplan

doi:10.1101/gad.1780509

Maintaining a stochastic neuronal cell fate decision

Daniel Vasiliauskas, Robert Johnston, Claude Desplan

Research output: Contribution to journal › Review article › peer-review

Abstract

Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcription factor, NSY-7, that acts to stabilize a stochastic subtype choice in AWC chemo- sensory neurons in Caenorhabditis elegans.

Original language	English (US)
Pages (from-to)	385-390
Number of pages	6
Journal	Genes and Development
Volume	23
Issue number	4
DOIs	https://doi.org/10.1101/gad.1780509
State	Published - Feb 15 2009

Keywords

; activity-dependent gene expression
Homeodomain
Olfactory development
Transcriptional maintenance
Transcriptional repression
cGMP-dependent protein kinase

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1780509

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AU - Johnston, Robert

AU - Desplan, Claude

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AB - Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcription factor, NSY-7, that acts to stabilize a stochastic subtype choice in AWC chemo- sensory neurons in Caenorhabditis elegans.

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KW - Homeodomain

KW - Olfactory development

KW - Transcriptional maintenance

KW - Transcriptional repression

KW - cGMP-dependent protein kinase

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Maintaining a stochastic neuronal cell fate decision

Abstract

Keywords

ASJC Scopus subject areas

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