Sensory systems generally contain a number of neuronal subtypes that express distinct sensory receptor proteins. This diversity is generated through deterministic and stochastic cell fate choices, while maintaining the subtype often requires a distinct mechanism. In a study published in the February 1, 2009, issue of Genes & Development, Lesch and colleagues (pp. 345-358) describe a new transcription factor, NSY-7, that acts to stabilize a stochastic subtype choice in AWC chemo- sensory neurons in Caenorhabditis elegans.
- ; activity-dependent gene expression
- Olfactory development
- Transcriptional maintenance
- Transcriptional repression
- cGMP-dependent protein kinase
ASJC Scopus subject areas
- Developmental Biology