Mammalian adaptation in the PB2 gene of avian H5N1 influenza virus

Ji Young Min, Celia Santos, Adam Fitch, Alan Twaddle, Yoshiko Toyoda, Jay V. DePasse, Elodie Ghedin, Kanta Subbarao

Research output: Contribution to journalArticlepeer-review


The substitution of glutamic acid (E) for lysine (K) at position 627 of the PB2 protein of avian H5N1 viruses has been identified as a virulence and host range determinant for infection of mammals. Here, we report that the E-to-K host-adaptive mutation in the PB2 gene appeared from day 4 and 5 along the respiratory tracts of mice and was complete by day 6 postinoculation. This mutation correlated with efficient replication of the virus in mice.

Original languageEnglish (US)
Pages (from-to)10884-10888
Number of pages5
JournalJournal of virology
Issue number19
StatePublished - 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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