Mapping the chemistry of highly unsaturated pyrone polyketides

Aubry K. Miller, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


Highly unsaturated pyrone polyketides ('HUPPs') are a growing family of natural products derived from polyene precursors, often through pericyclic or ionic reaction cascades. We describe our extensive studies on this class of compounds, which have so far resulted in the total synthesis of 17 of its members.

Original languageEnglish (US)
Pages (from-to)2295-2316
Number of pages22
Issue number14
StatePublished - Sep 1 2006


  • Biomimetic synthesis
  • Cross-couplings
  • Electrocyclic reactions
  • Natural products
  • Reaction cascades

ASJC Scopus subject areas

  • Organic Chemistry


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