Mass Changes the Diffusion Coefficient of Particles with Ligand-Receptor Contacts in the Overdamped Limit

Sophie Marbach, Miranda Holmes-Cerfon

Research output: Contribution to journalArticlepeer-review

Abstract

Inertia does not generally affect the long-time diffusion of passive overdamped particles in fluids. Yet a model starting from the Langevin equation predicts a surprising property of particles coated with ligands that bind reversibly to surface receptors: heavy particles diffuse more slowly than light ones of the same size. We show this by simulation and by deriving an analytic formula for the mass-dependent diffusion coefficient in the overdamped limit. We estimate the magnitude of this effect for a range of biophysical ligand-receptor systems, and find it is potentially observable for tailored micronscale DNA-coated colloids.

Original languageEnglish (US)
Article number048003
JournalPhysical Review Letters
Volume129
Issue number4
DOIs
StatePublished - Jul 22 2022

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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