Mass Smallpox Vaccination and Cardiac Deaths, New York City, 1947

Lorna E. Thorpe, Farzad Mostashari, Adam M. Karpati, Steven P. Schwartz, Susan E. Manning, Melissa A. Marx, Thomas R. Frieden

Research output: Contribution to journalArticlepeer-review


In April 1947, during a smallpox outbreak in New York City (NYC), >6 million people were vaccinated. To determine whether vaccination increased cardiac death, we reviewed NYC death certificates for comparable periods in 1946, 1947, and 1948 (N = 81,529) and calculated adjusted relative death rates for the postvaccination period. No increases in cardiac deaths were observed.

Original languageEnglish (US)
Pages (from-to)917-920
Number of pages4
JournalEmerging Infectious Diseases
Issue number5
StatePublished - May 2004

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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