Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat

N. D. Macon; A. Schwartz; K. James; X. Tong; J. Charvet; J. Ricci

Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat

N. D. Macon, A. Schwartz, K. James, X. Tong, J. Charvet, J. Ricci

Research output: Contribution to conference › Paper › peer-review

Abstract

Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), or PDTEc, is a candidate bioresorbable polymer for use in small bone fracture fixation and is shown to generate a good hard tissue response in vivo. The general effect of the in vivo environment on bone pin prototypes made of either 44.2-kDa or 71.8-kDa weight-average molecular weight (Mw) PDTEc is determined through mechanical testing and gel permeation chromatography (GPC) analysis of retrieved specimens. Results indicate that the lower-molecular-weight material is useful in biodistribution studies of PDTEc degradation products. The higher-molecular-weight material is useful in further orthopedic device prototype development.

Original language	English (US)
Number of pages	1
State	Published - 1996
Event	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996

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Other	Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
City	Toronto, Can
Period	5/29/96 → 6/2/96

ASJC Scopus subject areas

General Materials Science

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Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat. / Macon, N. D.; Schwartz, A.; James, K. et al.
1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can.

Research output: Contribution to conference › Paper › peer-review

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title = "Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat",

abstract = "Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), or PDTEc, is a candidate bioresorbable polymer for use in small bone fracture fixation and is shown to generate a good hard tissue response in vivo. The general effect of the in vivo environment on bone pin prototypes made of either 44.2-kDa or 71.8-kDa weight-average molecular weight (Mw) PDTEc is determined through mechanical testing and gel permeation chromatography (GPC) analysis of retrieved specimens. Results indicate that the lower-molecular-weight material is useful in biodistribution studies of PDTEc degradation products. The higher-molecular-weight material is useful in further orthopedic device prototype development.",

author = "Macon, {N. D.} and A. Schwartz and K. James and X. Tong and J. Charvet and J. Ricci",

year = "1996",

language = "English (US)",

note = "Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) ; Conference date: 29-05-1996 Through 02-06-1996",

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T1 - Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat

AU - Macon, N. D.

AU - Schwartz, A.

AU - James, K.

AU - Tong, X.

AU - Charvet, J.

AU - Ricci, J.

PY - 1996

Y1 - 1996

N2 - Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), or PDTEc, is a candidate bioresorbable polymer for use in small bone fracture fixation and is shown to generate a good hard tissue response in vivo. The general effect of the in vivo environment on bone pin prototypes made of either 44.2-kDa or 71.8-kDa weight-average molecular weight (Mw) PDTEc is determined through mechanical testing and gel permeation chromatography (GPC) analysis of retrieved specimens. Results indicate that the lower-molecular-weight material is useful in biodistribution studies of PDTEc degradation products. The higher-molecular-weight material is useful in further orthopedic device prototype development.

AB - Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), or PDTEc, is a candidate bioresorbable polymer for use in small bone fracture fixation and is shown to generate a good hard tissue response in vivo. The general effect of the in vivo environment on bone pin prototypes made of either 44.2-kDa or 71.8-kDa weight-average molecular weight (Mw) PDTEc is determined through mechanical testing and gel permeation chromatography (GPC) analysis of retrieved specimens. Results indicate that the lower-molecular-weight material is useful in biodistribution studies of PDTEc degradation products. The higher-molecular-weight material is useful in further orthopedic device prototype development.

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M3 - Paper

AN - SCOPUS:0030399577

T2 - Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)

Y2 - 29 May 1996 through 2 June 1996

ER -

Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat

Abstract

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