Materials and devices for micro-invasive neural interfacing

Khalil B. Ramadi, Michael J. Cima

    Research output: Contribution to journalArticlepeer-review


    There is widespread research and popular interest in developing micro-invasive neural interfacing modalities. An increasing variety of probes have been developed and reported in the literature. Newer, smaller probes show significant benefit over larger ones in reducing tissue damage and scarring. A different set of obstacles arise, however, as probes become smaller. These include reliable insertion and robustness. This review articulates the impact of various design parameters (material, geometry, size) on probe insertion mechanisms, chronic viability, and glial scarring. We highlight various emerging technologies utilizing novel form factors including micron-scale interfaces and bio-inspired designs for probe insertion and steering.

    Original languageEnglish (US)
    Pages (from-to)2805-2816
    Number of pages12
    JournalMRS Advances
    Issue number51-52
    StatePublished - 2019


    • Biomedical
    • Biomimetic

    ASJC Scopus subject areas

    • General Materials Science
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering


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