Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring

Jacqueline E. Maye, Rebecca A. Betensky, Christopher M. Gidicsin, Joseph Locascio, J. Alex Becker, Lesley Pepin, Jeremy Carmasin, Dorene M. Rentz, Gad A. Marshall, Deborah Blacker, Reisa A. Sperling, Keith A. Johnson

Research output: Contribution to journalArticle

Abstract

Family history (FH) of dementia is a major risk factor for Alzheimer's disease, particularly when the FH is maternal and when the age of dementia onset (AO) is younger. This study tested whether brain amyloid-beta deposition, measured in vivo with 11C-Pittsburgh compound B (PiB), was associated with parental dementia and/or younger parental AO. Detailed FH and positron emission tomography (PiB) data were acquired in 147 nondemented aging individuals (mean age 75 ± 8). No participant had both positive maternal and paternal FH. A series of analyses revealed that those with maternal, but not paternal, FH had greater levels of PiB retention in a global cortical region than those without FH. PiB retention in maternal FH was not significantly greater than paternal FH. Younger maternal dementia AO was related to greater PiB retention in offspring, whereas younger paternal dementia AO was not. Overall, results suggest that not only is amyloid-beta burden greater in individuals with maternal FH, but also that the burden is greater in association with younger maternal AO.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalNeurobiology of Aging
Volume40
DOIs
StatePublished - Apr 1 2016

Keywords

  • Amyloid-beta
  • Family history
  • PET
  • PiB

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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  • Cite this

    Maye, J. E., Betensky, R. A., Gidicsin, C. M., Locascio, J., Becker, J. A., Pepin, L., Carmasin, J., Rentz, D. M., Marshall, G. A., Blacker, D., Sperling, R. A., & Johnson, K. A. (2016). Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring. Neurobiology of Aging, 40, 61-67. https://doi.org/10.1016/j.neurobiolaging.2015.12.013