Maternal serum markers, characteristics and morbidly adherent placenta in women with previa

D. J. Lyell; A. M. Faucett; R. J. Baer; Y. J. Blumenfeld; M. L. Druzin; Y. Y. El-Sayed; G. M. Shaw; R. J. Currier; L. L. Jelliffe-Pawlowski

doi:10.1038/jp.2015.40

Maternal serum markers, characteristics and morbidly adherent placenta in women with previa

D. J. Lyell, A. M. Faucett, R. J. Baer, Y. J. Blumenfeld, M. L. Druzin, Y. Y. El-Sayed, G. M. Shaw, R. J. Currier, L. L. Jelliffe-Pawlowski

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Abstract

To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.Study Design:Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.Result:In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ≥95th percentile (≥2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ≥95th percentile (≥1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ≥2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).Conclusion:Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.

Original language	English (US)
Pages (from-to)	570-574
Number of pages	5
Journal	Journal of Perinatology
Volume	35
Issue number	8
DOIs	https://doi.org/10.1038/jp.2015.40
State	Published - Aug 30 2015

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/jp.2015.40

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title = "Maternal serum markers, characteristics and morbidly adherent placenta in women with previa",

abstract = "To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.Study Design:Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.Result:In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ≥95th percentile (≥2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ≥95th percentile (≥1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ≥2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).Conclusion:Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.",

author = "Lyell, {D. J.} and Faucett, {A. M.} and Baer, {R. J.} and Blumenfeld, {Y. J.} and Druzin, {M. L.} and El-Sayed, {Y. Y.} and Shaw, {G. M.} and Currier, {R. J.} and Jelliffe-Pawlowski, {L. L.}",

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AU - Lyell, D. J.

AU - Faucett, A. M.

AU - Baer, R. J.

AU - Blumenfeld, Y. J.

AU - Druzin, M. L.

AU - El-Sayed, Y. Y.

AU - Shaw, G. M.

AU - Currier, R. J.

AU - Jelliffe-Pawlowski, L. L.

PY - 2015/8/30

Y1 - 2015/8/30

N2 - To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.Study Design:Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.Result:In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ≥95th percentile (≥2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ≥95th percentile (≥1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ≥2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).Conclusion:Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.

AB - To examine associations with morbidly adherent placenta (MAP) among women with placenta previa.Study Design:Women with MAP (cases) and previa alone (controls) were identified from a cohort of 236 714 singleton pregnancies with both first and second trimester prenatal screening, and live birth and hospital discharge records; pregnancies with aneuploidies and neural tube or abdominal wall defects were excluded. Logistic binomial regression was used to compare cases with controls.Result:In all, 37 cases with MAP and 699 controls with previa alone were included. Risk for MAP was increased among multiparous women with pregnancy-associated plasma protein-A (PAPP-A) ≥95th percentile (≥2.63 multiple of the median (MoM); adjusted OR (aOR) 8.7, 95% confidence interval (CI) 2.8 to 27.4), maternal-serum alpha fetoprotein (MS-AFP) ≥95th percentile (≥1.79 MoM; aOR 2.8, 95% CI 1.0 to 8.0), and 1 and ≥2 prior cesarean deliveries (CDs; aORs 4.4, 95% CI 1.5 to 13.6 and 18.4, 95% CI 5.9 to 57.5, respectively).Conclusion:Elevated PAPP-A, elevated MS-AFP and prior CDs are associated with MAP among women with previa.

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Maternal serum markers, characteristics and morbidly adherent placenta in women with previa

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