Maternal smoking and trisomy among spontaneously aborted conceptions

J. Kline, B. Levin, P. Shrout, Z. Stein, M. Susser, D. Warburton

Research output: Contribution to journalArticlepeer-review

Abstract

In a study of spontaneous abortions, we found an apparently robust association of trisomy with smoking that varies with maternal age. Among women under age 30, smoking either before or at the time of conception is less common in women aborting trisomic conceptions than in controls delivering at 28 weeks or later. Among older women, smoking is more common in women aborting trisomic conceptions than in controls. Our results point to an effect of smoking on the frequency of trisomic abortions that varies with age, and they suggest that the causes of recognized trisomic abortions differ in younger and older women.

Original languageEnglish (US)
Pages (from-to)421-431
Number of pages11
JournalAmerican Journal of Human Genetics
Volume35
Issue number3
StatePublished - 1983

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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